Journal article
Antigen-coated poly α-hydroxy acid based microparticles for heterologous prime-boost adenovirus based vaccinations
Biomaterials, Vol.34(10), pp.2524-2529
03/2013
DOI: 10.1016/j.biomaterials.2012.12.030
PMCID: PMC3557532
PMID: 23312902
Abstract
Adenoviruses show promising potential as vectors for cancer vaccines, however, their high immunogenicity can be problematic when it comes to homologous prime-boost strategies. In the studies presented here we show that heterologous prime-boost vaccinations involving ovalbumin (OVA)-antigen-coated microparticles as a prime, and adenovirus encoding OVA (AdOVA) as a boost, were equally as effective as homologous AdOVA prime-boosts at generating OVA-specific CD8+ T-cell responses, which translated into effective tumor protection. OVA-coated biodegradable poly α-hydroxy acid-based microparticles of varying chemistries, when used as primes in heterologous prime-boost vaccinations, were comparable in terms of promoting OVA-specific CD8+ T cells as well as providing protection against subsequent tumor challenge. These findings auger well for using poly α-hydroxy acid-based microparticles in prime-boost viral vaccination strategies geared toward the safer, and potentially more efficient, generation of anti-tumor immunity.
Details
- Title: Subtitle
- Antigen-coated poly α-hydroxy acid based microparticles for heterologous prime-boost adenovirus based vaccinations
- Creators
- Caitlin D LemkeSean M GearyVijaya B JoshiAliasger K Salem
- Resource Type
- Journal article
- Publication Details
- Biomaterials, Vol.34(10), pp.2524-2529
- DOI
- 10.1016/j.biomaterials.2012.12.030
- PMID
- 23312902
- PMCID
- PMC3557532
- NLM abbreviation
- Biomaterials
- ISSN
- 0142-9612
- eISSN
- 1878-5905
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000048, name: American Cancer Society, award: RSG-09-015-01-CDD; name: National Cancer Institute at the National Institutes of Health, award: 1R21CA13345-01, P50CA09727411
- Language
- English
- Date published
- 03/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Holden Comprehensive Cancer Center
- Record Identifier
- 9983985890902771
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