Journal article
Antigen presentation in cancer - mechanisms and clinical implications for immunotherapy
Nature reviews. Clinical oncology, Vol.20(9), pp.604-623
09/01/2023
DOI: 10.1038/s41571-023-00789-4
PMID: 37328642
Abstract
Immune-checkpoint inhibitors (ICIs) and other immunotherapies have revolutionized the treatment of patients with cancer. Nonetheless, most patients do not derive durable benefit, indicating a need for biomarkers to guide treatment selection. In this Review, the authors describe the role of antigen presentation in response to ICIs and other immunotherapies, with a focus on the role of molecular and/or genomic alterations affecting antigen presentation.
Over the past decade, the emergence of effective immunotherapies has revolutionized the clinical management of many types of cancers. However, long-term durable tumour control is only achieved in a fraction of patients who receive these therapies. Understanding the mechanisms underlying clinical response and resistance to treatment is therefore essential to expanding the level of clinical benefit obtained from immunotherapies. In this Review, we describe the molecular mechanisms of antigen processing and presentation in tumours and their clinical consequences. We examine how various aspects of the antigen-presentation machinery (APM) shape tumour immunity. In particular, we discuss genomic variants in HLA alleles and other APM components, highlighting their influence on the immunopeptidomes of both malignant cells and immune cells. Understanding the APM, how it is regulated and how it changes in tumour cells is crucial for determining which patients will respond to immunotherapy and why some patients develop resistance. We focus on recently discovered molecular and genomic alterations that drive the clinical outcomes of patients receiving immune-checkpoint inhibitors. An improved understanding of how these variables mediate tumour-immune interactions is expected to guide the more precise administration of immunotherapies and reveal potentially promising directions for the development of new immunotherapeutic approaches.
Details
- Title: Subtitle
- Antigen presentation in cancer - mechanisms and clinical implications for immunotherapy
- Creators
- Kailin Yang - Cleveland ClinicAhmed Halima - Cleveland ClinicTimothy A. Chan - Cleveland Clinic
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Clinical oncology, Vol.20(9), pp.604-623
- Publisher
- NATURE PORTFOLIO
- DOI
- 10.1038/s41571-023-00789-4
- PMID
- 37328642
- ISSN
- 1759-4774
- eISSN
- 1759-4782
- Number of pages
- 20
- Grant note
- ASCO Conquer Cancer Foundation RSNA Research Resident Grant Cleveland Clinic VeloSano Impact Award R35CA232097; R01CA205426; U54CA274513; T32CA094186 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 09/01/2023
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696573902771
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