Journal article
Antigen-specific B cell tumors of mice
Critical reviews in immunology, Vol.6(2), pp.105-121
1986
PMID: 3524998
Abstract
The topics covered in this review include: the origin and availability of murine B cell lymphomas bearing immunoglobulins of known antigen reactivity; their etiology and the role of antigen in lymphomagenesis; the extent to which such tumors are true analogs of normal B cells; and the knowledge of B cell differentiation which has been derived from the study of these cells. There is little or no evidence that B lymphomas with preselected antigen specificity can be induced at will. However, there is evidence that genetic factors influencing idiotype specific regulation can predispose particular subsets of B cells to neoplastic transformation, and thereby indirectly influence the antigen specificity of the resultant lymphomas. The bulk of evidence suggests that, except for growth control characteristics, recently derived B cell lymphomas retain many of the features of normal lymphocytes. Thus, mechanisms elucidated by study of lymphomas are probably reflective of normal B cell biology.
Details
- Title: Subtitle
- Antigen-specific B cell tumors of mice
- Creators
- G A BishopL W ArnoldG Haughton
- Resource Type
- Journal article
- Publication Details
- Critical reviews in immunology, Vol.6(2), pp.105-121
- Publisher
- United States
- PMID
- 3524998
- ISSN
- 1040-8401
- eISSN
- 2162-6472
- Language
- English
- Date published
- 1986
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001122702771
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