Journal article
Antigen-specific B-lymphocyte activation
Critical reviews in immunology, Vol.23(3), pp.149-197
2003
DOI: 10.1615/CritRevImmunol.v23.i3.10
PMID: 14584878
Abstract
B lymphocytes comprise a major component of the adaptive mammalian immune system, having the exclusive ability to produce and secrete immunoglobulins (Ig) of various forms (isotypes). This property alone renders B-cell activation critical to immunity, but the fully activated B cell also functions in antigen presentation and the production of a variety of cytokines and chemokines. There are many signals that must be coordinated to achieve and properly regulate antigen-specific B-lymphocyte activation and the development of humoral memory. This review seeks to summarize these components, and to highlight recent advances in each area that contribute to a greater understanding of the complex processes involved in B-cell activation.
Details
- Title: Subtitle
- Antigen-specific B-lymphocyte activation
- Creators
- Gail A Bishop - Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA. gail-bishop@uiowa.eduSokol A HaxhinastoLaura L StunzBruce S Hostager
- Resource Type
- Journal article
- Publication Details
- Critical reviews in immunology, Vol.23(3), pp.149-197
- Publisher
- United States
- DOI
- 10.1615/CritRevImmunol.v23.i3.10
- PMID
- 14584878
- ISSN
- 1040-8401
- eISSN
- 2162-6472
- Language
- English
- Date published
- 2003
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001110602771
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