Journal article
Antigenic and immunogenic properties of recombinant hepatitis A virus 14S and 70S subviral particles
Journal of virology, Vol.67(2), pp.1080-1085
02/1993
DOI: 10.1128/JVI.67.2.1080-1085.1993
PMCID: PMC237464
PMID: 7678298
Abstract
Hepatitis A virus (HAV) has an immunodominant neutralization antigenic site. By using a panel of monoclonal antibodies targeted against the HAV neutralization antigenic site, it was shown that three epitopes within this site are present on 14S subunits (pentamers of the structural unit). In contrast, two other epitopes within this site are formed upon assembly of 14S subunits into capsids. Thus, the epitopes recognized by these two monoclonal antibodies are formed either by a conformational change in the antigenic site or by the juxtaposition of epitope fragments present on different 14S subunits during assembly of 14S into 70S particles. Both 14S and 70S particles elicited HAV-neutralizing antibodies in mice; thus, these particles may be useful for HAV vaccine development.
Details
- Title: Subtitle
- Antigenic and immunogenic properties of recombinant hepatitis A virus 14S and 70S subviral particles
- Creators
- Jack T Stapleton - Research Service, Iowa City VA Medical Center, IowaVijay RainaPatricia L WinokurKathy WaltersDonna KlinzmanEliot RosenJames H McLinden
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.67(2), pp.1080-1085
- DOI
- 10.1128/JVI.67.2.1080-1085.1993
- PMID
- 7678298
- PMCID
- PMC237464
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Language
- English
- Date published
- 02/1993
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Medicine Administration; Internal Medicine
- Record Identifier
- 9984094637802771
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