Journal article
Antiinsectan alkaloids: Shearinines A-C and a new paxilline derivative from the ascostromata of Eupenicillium shearii
Tetrahedron, Vol.51(14), pp.3959-3968
1995
DOI: 10.1016/0040-4020(95)00138-X
Abstract
Four new antiinsectan indole alkaloids (
1–4) have been isolated from organic extracts of the sclerotioid ascostromata of
Eupenicillium shearii (NRRL 3324). These extracts also afforded five known, related metabolites (
5–9). The structures of the new compounds were determined through analysis of
1H NMR,
13C NMR, HMQC, and HMBC experiments. Compounds
1–9 were isolated from fractions displaying activity in dietary assays against the corn earworm
Helicoverpa zea and the dried-fruit beetle
Carpophilus hemipterus, and most of the compounds show potent activity in these assays. Shearinine A (
1) also exhibited activity in a topical assay against
H. zea, and shearinine B (
2) caused significant mortality in a leaf disk assay against the fall armyworm
Spodoptera frugiperda.
Four new alkaloids were isolated from the ascostromata of
Eupenicillium shearii. Shearinines A and B (1–2) exhibited antiinsectan activity against
Heticoverpa zea and
Spodoptera frugiperda.
Details
- Title: Subtitle
- Antiinsectan alkaloids: Shearinines A-C and a new paxilline derivative from the ascostromata of Eupenicillium shearii
- Creators
- Gilbert N BelofskyJames B GloerDonald T WicklowPatrick F Dowd
- Resource Type
- Journal article
- Publication Details
- Tetrahedron, Vol.51(14), pp.3959-3968
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0040-4020(95)00138-X
- ISSN
- 0040-4020
- eISSN
- 1464-5416
- Language
- English
- Date published
- 1995
- Academic Unit
- Chemistry
- Record Identifier
- 9984216679102771
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