Journal article
Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam and Comparators Tested Against Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates from United States Medical Centers in 2016-2018
Microbial drug resistance (Larchmont, N.Y.), Vol.27(3), pp.342-349
03/2021
DOI: 10.1089/mdr.2020.0217
PMID: 32762605
Abstract
Very few antimicrobial agents remain active against
and
in some geographic regions. We evaluated the
activity of ceftazidime-avibactam, ceftolozane-tazobactam, and comparator agents against 6,210
and 6,041
isolates consecutively collected from 85 U.S. medical centers across 37 states in 2016-2018. Antimicrobial susceptibility was determined by reference broth microdilution method.
isolates found to have elevated MICs for broad-spectrum cephalosporins were submitted to whole-genome sequencing analysis to detect resistance genes. Ceftazidime-avibactam (97.1% susceptible [S]) and ceftolozane-tazobactam (97.0%S) were the most active compounds against
and retained activity against meropenem-nonsusceptible (88.5-89.0%S), piperacillin-tazobactam-nonsusceptible (86.6-87.0%S), and other resistant subsets of isolates. The most active agents against
per CLSI criteria were ceftazidime-avibactam (>99.9%S), amikacin (98.4%S), and meropenem (97.1%S). Ceftolozane-tazobactam was active against 95.3% of
but showed limited activity against extended-spectrum β-lactamase and carbapenemase producers (82.9% and 0.0%S, respectively).
Details
- Title: Subtitle
- Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam and Comparators Tested Against Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates from United States Medical Centers in 2016-2018
- Creators
- Helio S Sader - JMI LaboratoriesCecilia G Carvalhaes - JMI LaboratoriesJennifer M Streit - JMI LaboratoriesTimothy B Doyle - JMI LaboratoriesMariana Castanheira - JMI Laboratories
- Resource Type
- Journal article
- Publication Details
- Microbial drug resistance (Larchmont, N.Y.), Vol.27(3), pp.342-349
- DOI
- 10.1089/mdr.2020.0217
- PMID
- 32762605
- ISSN
- 1076-6294
- eISSN
- 1931-8448
- Language
- English
- Date published
- 03/2021
- Academic Unit
- Pathology
- Record Identifier
- 9984183990202771
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