Antimicrobial Activity of Ceftolozane-Tazobactam and Comparators against Clinical Isolates of Haemophilus influenzae from the United States and Europe

Helio S Sader; Cecilia G Carvalhaes; Leonard R Duncan; Dee Shortridge

doi:10.1128/AAC.00211-20

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Antimicrobial Activity of Ceftolozane-Tazobactam and Comparators against Clinical Isolates of Haemophilus influenzae from the United States and Europe

Journal article

Open access

Peer reviewed

Antimicrobial Activity of Ceftolozane-Tazobactam and Comparators against Clinical Isolates of Haemophilus influenzae from the United States and Europe

Helio S Sader, Cecilia G Carvalhaes, Leonard R Duncan and Dee Shortridge

Antimicrobial agents and chemotherapy, Vol.64(5), e00211-20

04/21/2020

DOI: 10.1128/AAC.00211-20

PMCID: PMC7179628

PMID: 32094135

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https://pmc.ncbi.nlm.nih.gov/articles/PMC7179628/View

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Abstract

Nine hundred clinical isolates from 83 U.S. and European medical centers were tested for susceptibility by reference broth microdilution methods against ceftolozane-tazobactam and comparators. Results were stratified by β-lactamase production and infection type. Overall, ceftolozane-tazobactam MIC values were 0.12/0.25 mg/liter, and 99.0% of isolates were inhibited at the susceptible breakpoint of ≤0.5 mg/liter; the highest MIC value was only 2 mg/liter. Our results support using ceftolozane-tazobactam to treat infections.

Europe

United States

Anti-Bacterial Agents - therapeutic use

Cephalosporins - therapeutic use

Drug Resistance, Multiple, Bacterial - genetics

Haemophilus Infections - drug therapy

Haemophilus influenzae - drug effects

Haemophilus influenzae - genetics

Haemophilus influenzae - isolation & purification

Humans

Microbial Sensitivity Tests

Tazobactam - therapeutic use

Details

Title: Subtitle: Antimicrobial Activity of Ceftolozane-Tazobactam and Comparators against Clinical Isolates of Haemophilus influenzae from the United States and Europe
Creators: Helio S Sader - JMI Laboratories
Cecilia G Carvalhaes - JMI Laboratories
Leonard R Duncan - JMI Laboratories
Dee Shortridge - JMI Laboratories
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.64(5), e00211-20
DOI: 10.1128/AAC.00211-20
PMID: 32094135
PMCID: PMC7179628
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Grant note: DOI: 10.13039/100009947, name: Merck & Co., Inc. | Merck Sharp and Dohme
Language: English
Date published: 04/21/2020
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984185276002771

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