Journal article
Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians
Open forum infectious diseases, Vol.5(4), pp.ofy068-ofy068
04/01/2018
DOI: 10.1093/ofid/ofy068
PMCID: PMC5917774
PMID: 29732380
Abstract
Background. In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of antimicrobial agents.
Methods. We used a web-based survey of ID physician members of the Emerging Infections Network in 2016.
Results. Of the 701 of 1597 members (44%) who responded, 70% reported the need to modify their antimicrobial choice because of a shortage in the prior 2 years. A majority (73%) reported the shortages affected patient care or outcomes by the use of broader-spectrum (75%), more costly (58%), less effective second-line (45%), or more toxic agents (37%). The most commonly reported antimicrobials in short supply were piperacillin-tazobactam, ampicillin-sulbactam, meropenem, cefotaxime, and cefepime. Respondents learned of shortages from hospital notification, from a colleague, contact from pharmacy after ordering the agent in short supply, or FDA or other website. The antimicrobial stewardship programs (ASPs) of a majority (83%) of respondents' institutions had developed approaches to deal with shortages. Although 71% indicated that communications were sufficient, most (87%) did not perceive any improvement in communications about shortages since the 2012 FDA requirement.
Conclusions. The persistence of antimicrobial agent shortages reported by ID physicians is disturbing as is the resulting need to use broader-spectrum or more toxic agents. The prominent role of ASPs in helping to deal with shortages, effective communication channels, and the lack of perceived improvement in FDA's communication strategy merit further consideration.
Details
- Title: Subtitle
- Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians
- Creators
- Adi V. Gundlapalli - University of UtahSusan E. Beekmann - University of IowaDonald R. Graham - Springfield ClinicPhilip M. Polgreen - Roy J. and Lucille A. Carver College of MedicineEmerging Infections Network
- Resource Type
- Journal article
- Publication Details
- Open forum infectious diseases, Vol.5(4), pp.ofy068-ofy068
- DOI
- 10.1093/ofid/ofy068
- PMID
- 29732380
- PMCID
- PMC5917774
- NLM abbreviation
- Open Forum Infect Dis
- ISSN
- 2328-8957
- eISSN
- 2328-8957
- Publisher
- Oxford University Press
- Number of pages
- 5
- Grant note
- 1 U50 CK000477 / Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA I50HX001240 / VA Center of Innovation Award from the Health Services Research and Development of the Office of Research and Development of the US Department of Veterans Affairs
- Language
- English
- Date published
- 04/01/2018
- Academic Unit
- Infectious Diseases; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984359819202771
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