Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004

James R Johnson; Mark R Sannes; Cynthia Croy; Brian Johnston; Connie Clabots; Michael A Kuskowski; Jeff Bender; Kirk E Smith; Patricia L Winokur; Edward A Belongia

doi:10.3201/eid1306.061576

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Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004

Journal article

Open access

Peer reviewed

Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004

James R Johnson, Mark R Sannes, Cynthia Croy, Brian Johnston, Connie Clabots, Michael A Kuskowski, Jeff Bender, Kirk E Smith, Patricia L Winokur and Edward A Belongia

Emerging infectious diseases, Vol.13(6), pp.838-846

06/2007

DOI: 10.3201/eid1306.061576

PMCID: PMC2792839

PMID: 17553221

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Abstract

Similarities were found between drug-resistant E . coli from humans and poultry products. The food supply, including poultry products, may transmit antimicrobial drug–resistant Escherichia coli to humans. To assess this hypothesis, 931 geographically and temporally matched E. coli isolates from human volunteers (hospital inpatients and healthy vegetarians) and commercial poultry products (conventionally raised or raised without antimicrobial drugs) were tested by PCR for phylogenetic group (A, B1, B2, D) and 60 virulence genes associated with extraintestinal pathogenic E. coli . Isolates resistant to trimethoprim-sulfamethoxazole, quinolones, and extended-spectrum cephalosporins (n = 331) were compared with drug-susceptible isolates (n = 600) stratified by source. Phylogenetic and virulence markers of drug-susceptible human isolates differed considerably from those of human and poultry isolates. In contrast, drug-resistant human isolates were similar to poultry isolates, and drug-susceptible and drug-resistant poultry isolates were largely indistinguishable. Many drug-resistant human fecal E. coli isolates may originate from poultry, whereas drug-resistant poultry-source E. coli isolates likely originate from susceptible poultry-source precursors.

antimicrobial drug resistance

poultry

virulence

foodborne disease

phylogenetics

zoonoses

Escherichia coli infections

Research

PCR

molecular fingerprinting

Details

Title: Subtitle: Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004
Creators: James R Johnson - Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
Mark R Sannes - Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
Cynthia Croy - Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
Brian Johnston - Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
Connie Clabots - Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
Michael A Kuskowski - Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
Jeff Bender - University of Minnesota, Saint Paul, Minnesota, USA
Kirk E Smith - Minnesota Department of Health, Saint Paul, Minnesota, USA
Patricia L Winokur - University of Iowa, Iowa City, Iowa, USA
Edward A Belongia - Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.13(6), pp.838-846
DOI: 10.3201/eid1306.061576
PMID: 17553221
PMCID: PMC2792839
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Publisher: Centers for Disease Control and Prevention
Alternative title: Drug-Resistant E. coli from Humans and Poultry
Language: English
Date published: 06/2007
Academic Unit: Infectious Diseases; Medicine Administration; Internal Medicine
Record Identifier: 9984094664702771

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