Antimicrobial Nonsusceptibility of Gram-Negative Bloodstream Isolates, Veterans Health Administration System, United States, 2003-2013

Michihiko Goto; Jennifer S McDanel; Daniel J Livorsi; Michael E Ohl; Brice F Beck; Kelly K Richardson; Bruce Alexander; Eli N Perencevich; Makoto M Jones

doi:10.3201/eid2311.161214

Back

Antimicrobial Nonsusceptibility of Gram-Negative Bloodstream Isolates, Veterans Health Administration System, United States, 2003-2013

Journal article

Open access

Peer reviewed

Antimicrobial Nonsusceptibility of Gram-Negative Bloodstream Isolates, Veterans Health Administration System, United States, 2003-2013

Michihiko Goto, Jennifer S McDanel, Daniel J Livorsi, Michael E Ohl, Brice F Beck, Kelly K Richardson, Bruce Alexander, Eli N Perencevich and Makoto M Jones

Emerging Infectious Diseases, Vol.23(11), pp.1815-1825

2017

DOI: 10.3201/eid2311.161214

PMID: 29047423

Files and links (1)

url

https://doi.org/10.3201/eid2311.161214View

Published (Version of record) Open Access

Abstract

Bacteremia caused by gram-negative bacteria is associated with serious illness and death, and emergence of antimicrobial drug resistance in these bacteria is a major concern. Using national microbiology and patient data for 2003-2013 from the US Veterans Health Administration, we characterized nonsusceptibility trends of community-acquired, community-onset; healthcare-associated, community-onset; and hospital-onset bacteremia for selected gram-negative bacteria (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, and Acinetobacter spp.). For 47,746 episodes of bacteremia, the incidence rate was 6.37 episodes/10,000 person-years for community-onset bacteremia and 4.53 episodes/10,000 patient-days for hospital-onset bacteremia. For Klebsiella spp., P. aeruginosa, and Acinetobacter spp., we observed a decreasing proportion of nonsusceptibility across nearly all antimicrobial drug classes for patients with healthcare exposure; trends for community-acquired, community-onset isolates were stable or increasing. The role of infection control and antimicrobial stewardship efforts in inpatient settings in the decrease in drug resistance rates for hospital-onset isolates needs to be determined.

Bacteria

Drug resistance in microorganisms

Health aspects

Escherichia coli

Details

Title: Subtitle: Antimicrobial Nonsusceptibility of Gram-Negative Bloodstream Isolates, Veterans Health Administration System, United States, 2003-2013
Creators: Michihiko Goto
Jennifer S McDanel
Daniel J Livorsi
Michael E Ohl
Brice F Beck
Kelly K Richardson
Bruce Alexander
Eli N Perencevich
Makoto M Jones
Resource Type: Journal article
Publication Details: Emerging Infectious Diseases, Vol.23(11), pp.1815-1825
DOI: 10.3201/eid2311.161214
PMID: 29047423
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Publisher: U.S. National Center for Infectious Diseases
Number of pages: 11
Copyright: Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.
Language: English
Date published: 2017
Description audience: Academic; Professional
Academic Unit: Pharmacy; Psychiatry; Epidemiology; Internal Medicine
Record Identifier: 9983779289402771

Metrics

33 Record Views

24 Times Cited - Web of Science