Antimicrobial Susceptibility of Pseudomonas aeruginosa to Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Piperacillin-Tazobactam, and Meropenem Stratified by U.S. Census Divisions: Results from the 2017 INFORM Program

Helio S Sader; Robert K Flamm; Cecilia G Carvalhaes; Mariana Castanheira

doi:10.1128/AAC.01587-18

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Antimicrobial Susceptibility of Pseudomonas aeruginosa to Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Piperacillin-Tazobactam, and Meropenem Stratified by U.S. Census Divisions: Results from the 2017 INFORM Program

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Antimicrobial Susceptibility of Pseudomonas aeruginosa to Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Piperacillin-Tazobactam, and Meropenem Stratified by U.S. Census Divisions: Results from the 2017 INFORM Program

Helio S Sader, Robert K Flamm, Cecilia G Carvalhaes and Mariana Castanheira

Antimicrobial agents and chemotherapy, Vol.62(12), e01587-18

12/2018

DOI: 10.1128/AAC.01587-18

PMCID: PMC6256773

PMID: 30224535

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Abstract

Pseudomonas aeruginosa isolates ( n = 1,909) were collected from 70 U.S. medical centers, and their susceptibilities were tested using the broth microdilution method. ABSTRACT Pseudomonas aeruginosa isolates ( n = 1,909) were collected from 70 U.S. medical centers, and their susceptibilities were tested using the broth microdilution method. Ceftazidime-avibactam (MIC 50 /MIC 90 , 2/8 mg/liter) and ceftolozane-tazobactam (MIC 50 /MIC 90 , 0.5/2 mg/liter) were the most active (i.e., had the highest susceptibility rates) compounds after colistin, with national susceptibility rates of 96.9% and 97.5%, respectively. Overall, piperacillin-tazobactam (MIC 50 /MIC 90 , 4/128 mg/liter) and meropenem (MIC 50 /MIC 90 , 0.5/16 mg/liter) were active against 77.5% and 76.0% of the isolates, respectively. Susceptibility variations across census divisions were documented for many antimicrobials.

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Title: Subtitle: Antimicrobial Susceptibility of Pseudomonas aeruginosa to Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Piperacillin-Tazobactam, and Meropenem Stratified by U.S. Census Divisions: Results from the 2017 INFORM Program
Creators: Helio S Sader - JMI Laboratories
Robert K Flamm - JMI Laboratories
Cecilia G Carvalhaes - JMI Laboratories
Mariana Castanheira - JMI Laboratories
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.62(12), e01587-18
DOI: 10.1128/AAC.01587-18
PMID: 30224535
PMCID: PMC6256773
ISSN: 0066-4804
eISSN: 1098-6596
Grant note: DOI: 10.13039/100007819, name: Allergan
Language: English
Date published: 12/2018
Academic Unit: Pathology
Record Identifier: 9984185176402771

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