Journal article
Antimicrobial activity of gatifloxacin compared to seven other compounds tested against gram-positive organisms isolated at 10 cancer-treatment centers
Diagnostic microbiology and infectious disease, Vol.34(1), pp.37-43
05/1999
DOI: 10.1016/S0732-8893(99)00010-3
PMID: 10342106
Abstract
Gram-positive bacterial pathogens are important causes of disease in cancer patients and are becoming increasingly resistant to available antimicrobial agents. We examined the in vitro activity of gatifloxacin, a new fluoroquinolone, compared with other quinolones, ceftazidime, and traditional Gram-positive-active agents tested against pathogens isolated from patients at 10 cancer treatment hospitals in the United States. A total of 1,128 Gram-positive isolates were tested by the E-test method (AB BIODISK, Solna, Sweden) with results validated by concurrent quality control strain analysis. Gatifloxacin was more potent than either ciprofloxacin or levofloxacin against all Gram-positive species. Vancomycin was the most active agent tested against all species except Bacillus spp., which were more susceptible to the fluoroquinolones. When tested against these Gram-positive pathogens from patients with cancer, the spectrum of gatifloxacin was also greater than that of levofloxacin and ciprofloxacin. Gatifloxacin may have a role as part of prophylactic or therapeutic antimicrobial regimens for selected cancer patients with Gram-positive infections.
Details
- Title: Subtitle
- Antimicrobial activity of gatifloxacin compared to seven other compounds tested against gram-positive organisms isolated at 10 cancer-treatment centers
- Creators
- Daniel J Diekema - Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USARonald N JonesKenneth V I Rolston
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.34(1), pp.37-43
- Publisher
- United States
- DOI
- 10.1016/S0732-8893(99)00010-3
- PMID
- 10342106
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Language
- English
- Date published
- 05/1999
- Academic Unit
- Infectious Diseases; Pathology; Internal Medicine
- Record Identifier
- 9983986263402771
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