Antimicrobial and Cytotoxic Potential of Eucalyptus Essential Oil-Based Nanoemulsions for Mouthwashes Application

Dione Glauco Batista; William Gustavo Sganzerla; Lysa Ribeiro da Silva; Yasmin Gabriele Schmitt Vieira; Aline R. Almeida; Diogo Dominguini; Luciane Ceretta; Adriana Castro Pinheiro; Fabiano Cleber Bertoldi; Daniela Becker; Dachamir Hotza; Michael Ramos Nunes; Cleonice Gonçalves da Rosa; Anelise Viapiana Masiero

doi:10.3390/antibiotics13100942

Back

Antimicrobial and Cytotoxic Potential of Eucalyptus Essential Oil-Based Nanoemulsions for Mouthwashes Application

Journal article

Open access

Peer reviewed

Antimicrobial and Cytotoxic Potential of Eucalyptus Essential Oil-Based Nanoemulsions for Mouthwashes Application

Dione Glauco Batista, William Gustavo Sganzerla, Lysa Ribeiro da Silva, Yasmin Gabriele Schmitt Vieira, Aline R. Almeida, Diogo Dominguini, Luciane Ceretta, Adriana Castro Pinheiro, Fabiano Cleber Bertoldi, Daniela Becker, …

Antibiotics (Basel), Vol.13(10), 942

10/08/2024

DOI: 10.3390/antibiotics13100942

PMCID: PMC11504657

PMID: 39452209

Files and links (1)

url

https://doi.org/10.3390/antibiotics13100942View

Published (Version of record) Open Access

Abstract

Objective: An eucalyptus essential oil-based nanoemulsion was produced and evaluated for its antimicrobial properties against Streptococcus mutans and its cytotoxicity in the surface mucous cells of rabbits. Methods: The essential oil-based nanoemulsion was synthesized with two species of eucalyptus—Eucalyptus citriodora and Eucalyptus globulus—followed by physicochemical characterization and the determination of antimicrobial activity and cell viability. Subsequently, the mouthwash formulations (fluoride and fluoride-free) were functionalized with the nanoemulsion, and their in vitro antimicrobial actions were evaluated against S. mutans. Results: The nanoemulsion presented an average particle size of around 100 nm, a polydispersity index close to 0.3, a zeta potential between −19 and −30 mV, a pH close to 7, a spherical shape, and a cell viability above 50%. The antimicrobial activity analysis showed that the nanoemulsion was effective in the control of S. mutans. The mouthwashes functionalized with the nanoemulsion also presented bacteriostatic and bactericidal properties. Conclusions: The bio-based material produced with eucalyptus essential oil presented adequate physicochemical characteristics, with the potential to be used as an innovative material in preventive dentistry, contributing to the maintenance of oral and systemic health.

nanotechnology

preventive dentistry

antioxidant

bioactive compounds

Details

Title: Subtitle: Antimicrobial and Cytotoxic Potential of Eucalyptus Essential Oil-Based Nanoemulsions for Mouthwashes Application
Creators: Dione Glauco Batista
William Gustavo Sganzerla - Universidade Estadual de Campinas (UNICAMP)
Lysa Ribeiro da Silva
Yasmin Gabriele Schmitt Vieira
Aline R. Almeida
Diogo Dominguini - Universidade do Extremo Sul Catarinense
Luciane Ceretta - Universidade do Extremo Sul Catarinense
Adriana Castro Pinheiro - Universidade Federal de Pelotas
Fabiano Cleber Bertoldi - Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina
Daniela Becker - Universidade do Estado de Santa Catarina
Dachamir Hotza - Universidade Federal de Santa Catarina
Michael Ramos Nunes - Universidade Federal de Santa Catarina
Cleonice Gonçalves da Rosa - Universidade do Planalto Catarinense
Anelise Viapiana Masiero - University of Iowa
Resource Type: Journal article
Publication Details: Antibiotics (Basel), Vol.13(10), 942
DOI: 10.3390/antibiotics13100942
PMID: 39452209
PMCID: PMC11504657
NLM abbreviation: Antibiotics (Basel)
ISSN: 2079-6382
eISSN: 2079-6382
Publisher: MDPI
Grant note: Fundacao de Amparo a Pesquisa e Inovacao do Estado Santa Catarina (FAPESC): FAPESC 12/2020 TO2021TR1482, FAPESC 12/2020 TO2021TR001430, FAPESC 15/2021 TO2021TR001220, FAPESC 54/2022 TO2023TR000648, FAPESC 54/2022 TO2023TR000883, FAPESC 54/2022 TO2023TR000884, FAPESC 15/2023 TO2023TR001418, FAPESC 15/2023 TO2023TR001518
This research was funded by Fundacao de Amparo a Pesquisa e Inovacao do Estado Santa Catarina (FAPESC) grant numbers FAPESC 12/2020 TO2021TR1482, FAPESC 12/2020 TO2021TR001430, FAPESC 15/2021 TO2021TR001220, FAPESC 54/2022 TO2023TR000648, FAPESC 54/2022 TO2023TR000883, FAPESC 54/2022 TO2023TR000884, FAPESC 15/2023 TO2023TR001418, and FAPESC 15/2023 TO2023TR001518.
Language: English
Date published: 10/08/2024
Academic Unit: Endodontics
Record Identifier: 9984722575202771

Metrics

23 Record Views

10 Times Cited - Web of Science