Journal article
Antimicrobial efficacy of platinum‐doped silver nanoparticles
Journal of biomedical materials research. Part B, Applied biomaterials, Vol.108(8), pp.3393-3401
11/2020
DOI: 10.1002/jbm.b.34674
PMCID: PMC7719576
PMID: 32618123
Abstract
Silver nanoparticles (AgNPs) have been proposed to combat oral infection due to their efficient ionic silver (Ag+) release. However, concentrations required for antimicrobial efficacy may not be therapeutically viable. In this work, platinum‐doped silver nanoparticles (Pt‐AgNPs) were explored to evaluate their potential for enhanced Ag+ release, which could lead to enhanced antimicrobial efficacy against S. aureus, P. aeruginosa, and E. coli. AgNPs doped with 0.5, 1, and 2 mol% platinum (Pt0.5‐AgNPs, Pt1‐AgNPs, and Pt2‐AgNPs) were synthesized by a chemical reduction method. Transmission electron microscopy revealed mixed morphologies of spherical, oval, and ribbon‐like nanostructures. Surface‐enhanced Raman scattering revealed that the surface of Pt‐AgNPs was covered with up to 93% Pt. The amount of Ag+ released increased 16.3‐fold for Pt2‐AgNPs, compared to AgNPs. The initial lag phase in bacterial growth curve was prolonged for Pt‐AgNPs. This is consistent with a Ag+ release profile that exhibited an initial burst followed by sustained release. Doping AgNPs with platinum significantly increased the antimicrobial efficacy against all species. Pt2‐AgNPs exhibited the lowest minimum inhibitory concentrations, followed by Pt1‐AgNPs, Pt0.5‐AgNPs, and AgNPs, respectively. Doping AgNPs with a small amount of platinum promoted the release of Ag+, based on the sacrificial anodic effect, and subsequently enhanced their antimicrobial efficacy.
Details
- Title: Subtitle
- Antimicrobial efficacy of platinum‐doped silver nanoparticles
- Creators
- Kan Wongkamhaeng - University of Iowa College of DentistryJunnan Wang - University of Iowa, College of Liberal Arts and SciencesJeffrey A Banas - University of Iowa College of DentistryDeborah V Dawson - University of Iowa College of DentistryJulie A Holloway - University of Iowa College of DentistryAmanda J Haes - University of Iowa, College of Liberal Arts and SciencesIsabelle Denry - University of Iowa College of Dentistry
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, Vol.108(8), pp.3393-3401
- DOI
- 10.1002/jbm.b.34674
- PMID
- 32618123
- PMCID
- PMC7719576
- NLM abbreviation
- J Biomed Mater Res B Appl Biomater
- ISSN
- 1552-4973
- eISSN
- 1552-4981
- Publisher
- John Wiley & Sons, Inc
- Number of pages
- 9
- Language
- English
- Date published
- 11/2020
- Academic Unit
- Biostatistics; Prosthodontics; Pediatric Dentistry; Chemistry; Dental Research
- Record Identifier
- 9984216694502771
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