Antimicrobial peptides in animals and their role in host defences

Kim A Brogden; Mark Ackermann; Paul B McCray; Brian F Tack

doi:10.1016/S0924-8579(03)00180-8

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Antimicrobial peptides in animals and their role in host defences

Journal article

Peer reviewed

Antimicrobial peptides in animals and their role in host defences

Kim A Brogden, Mark Ackermann, Paul B McCray and Brian F Tack

International journal of antimicrobial agents, Vol.22(5), pp.465-478

2003

DOI: 10.1016/S0924-8579(03)00180-8

PMID: 14602364

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Abstract

Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. These peptides differ in size, composition, mechanisms of activity and range of antimicrobial specificities. They are expressed in many tissues, polymorphonuclear leukocytes, macrophages and mucosal epithelial cells. There is a small group of anionic antimicrobial peptides found in ruminants and a much larger group of cationic antimicrobial peptides found in all domesticated animals. The cationic peptides include linear, helical peptides, linear peptides rich in proline and cysteine-stabilized peptides with a β-sheet and are commonly referred to as cathelicidins and defensins. These peptides are generally broad-spectrum for Gram-positive bacteria, Gram-negative bacteria and fungi (e.g. myeloid antimicrobial peptides, α-, β-defensins, and protegrins) or are specific to one of these groups (e.g. porcine cecropin P1, Bac5, Bac7, PR-39 and prophenin).

Innate defence

Defensins

Cathelicidins

Anionic peptides

Cationic peptides

Antimicrobial peptides

Livestock

Domesticated animals

Details

Title: Subtitle: Antimicrobial peptides in animals and their role in host defences
Creators: Kim A Brogden - Respiratory Diseases of Livestock Research Unit, U.S. Department of Agriculture, Agricultural Research Service, National Animal Disease Center, P.O. Box 70, Ames, Iowa 50010, USA
Mark Ackermann - Department of Veterinary Pathology, Iowa State University, Ames, Iowa 50011, USA
Paul B McCray - Department of Pediatrics, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
Brian F Tack - Department of Microbiology, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
Resource Type: Journal article
Publication Details: International journal of antimicrobial agents, Vol.22(5), pp.465-478
DOI: 10.1016/S0924-8579(03)00180-8
PMID: 14602364
NLM abbreviation: Int J Antimicrob Agents
ISSN: 0924-8579
eISSN: 1872-7913
Publisher: Elsevier B.V
Language: English
Date published: 2003
Academic Unit: Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Periodontics; Internal Medicine
Record Identifier: 9984093481402771

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