Antimicrobial resistance and molecular epidemiology of Staphylococcus aureus from Ulaanbaatar, Mongolia

Rajeshwari Nair; Blake M Hanson; Karly Kondratowicz; Altantsetseg Dorjpurev; Bulgan Davaadash; Battumur Enkhtuya; Odgerel Tundev; Tara C Smith

doi:10.7717/peerj.176

Back

Antimicrobial resistance and molecular epidemiology of Staphylococcus aureus from Ulaanbaatar, Mongolia

Journal article

Open access

Peer reviewed

Antimicrobial resistance and molecular epidemiology of Staphylococcus aureus from Ulaanbaatar, Mongolia

Rajeshwari Nair, Blake M Hanson, Karly Kondratowicz, Altantsetseg Dorjpurev, Bulgan Davaadash, Battumur Enkhtuya, Odgerel Tundev and Tara C Smith

PeerJ (San Francisco, CA), Vol.1(1), pp.e176-e176

2014

DOI: 10.7717/peerj.176

PMCID: PMC3796364

PMID: 24133636

Files and links (1)

url

https://doi.org/10.7717/peerj.176View

Published (Version of record) Open Access

Abstract

This study aimed to characterize Staphylococcus aureus ( S. aureus ) strains isolated from human infections in Mongolia. Infection samples were collected at two time periods (2007–08 and 2011) by the National Center for Communicable Diseases (NCCD) in Ulaanbaatar, Mongolia. S. aureus isolates were characterized using polymerase chain reaction (PCR) for mecA , PVL, and sasX genes and tested for agr functionality. All isolates were also spa typed. A subset of isolates selected by frequency of spa types was subjected to antimicrobial susceptibility testing and multilocus sequence typing. Among 251 S. aureus isolates, genotyping demonstrated methicillin resistance in 8.8% of isolates (22/251). Approximately 28% of the tested S. aureus isolates were observed to be multidrug resistant (MDR). Sequence type (ST) 154 ( spa t667) was observed to be a strain with high virulence potential, as all isolates for this spa type were positive for PVL, had a functional agr system and 78% were MDR. S. aureus isolates of ST239 ( spa t037) were observed to cause infections and roughly 60% had functional agr system with a greater proportion being MDR. Additionally, new multilocus sequence types and new spa types were identified, warranting continued surveillance for S. aureus in this region.

Public Health

Mongolia

MRSA infections

Microbiology

Global Health

Hospital infections

Molecular epidemiology

Infectious Diseases

Antimicrobial resistance

Epidemiology

Staphylococcus aureus

Details

Title: Subtitle: Antimicrobial resistance and molecular epidemiology of Staphylococcus aureus from Ulaanbaatar, Mongolia
Creators: Rajeshwari Nair - ,
Blake M Hanson - ,
Karly Kondratowicz - ,
Altantsetseg Dorjpurev - ,
Bulgan Davaadash - ,
Battumur Enkhtuya - ,
Odgerel Tundev - ,
Tara C Smith - ,
Resource Type: Journal article
Publication Details: PeerJ (San Francisco, CA), Vol.1(1), pp.e176-e176
DOI: 10.7717/peerj.176
PMID: 24133636
PMCID: PMC3796364
NLM abbreviation: PeerJ
ISSN: 2167-8359
eISSN: 2167-8359
Publisher: PeerJ Inc
Grant note: Stanley Graduate Award for International Research University of Iowa
Language: English
Date published: 2014
Academic Unit: Epidemiology; General Internal Medicine; Internal Medicine
Record Identifier: 9984094352002771

Metrics

46 Record Views

7 Times Cited - Web of Science