Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)

Helio S Sader; Ronald N Jones; Patricia L Winokur; Michael A Pfaller; Gary V Doern; Timothy Barrett; SENTRY Study Group, Latin America

doi:10.1111/j.1469-0691.1999.tb00177.x

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Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)

Journal article

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Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)

Helio S Sader, Ronald N Jones, Patricia L Winokur, Michael A Pfaller, Gary V Doern, Timothy Barrett and SENTRY Study Group, Latin America

Clinical microbiology and infection, Vol.5(8), pp.478-487

08/1999

DOI: 10.1111/j.1469-0691.1999.tb00177.x

PMID: 11856291

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Abstract

Objectives: To evaluate the antimicrobial susceptibility patterns among 469 pathogens isolated as a significant cause of urinary tract infections in 10 Latin American medical centers. Methods: Consecutively collected isolates were susceptibility tested by broth microdilution methods, and selected isolates were characterized by molecular typing methods. Results: Escherichia coli and Klebsiella spp. isolates revealed high rates of resistance to broad‐spectrum penicillins and to fluoroquinolones. Ceftazidime MICs of ≥2 mg/L, suggesting the production of extended‐spectrum β‐lactamases (ESBLs), were observed in 37.7% of K. pneumoniae and 8.3% of Escherichia coli isolates. Enterobacter spp. isolates were characterized by high resistance rates to ciprofloxacin (35%) and to ceftazidime (45%), but they generally remained susceptible to cefepime (95% susceptible). Pseudomonas aeruginosa and Acinetobacter spp. were highly resistant to ciprofloxacin and ceftazidime. Imipenem was active against 80% of P. aeruginosa and 93% of Acinetobacter spp. isolates. Conclusions: Our results demonstrate a high level of resistance to various classes of antimicrobial agents among isolates causing nosocomial urinary tract infections in Latin American hospitals. Clonal dissemination of ESBL‐producing K. pneumoniae strains was infrequent.

Urinary tract infection

SENTRY Antimicrobial Surveillance Program

antimicrobial resistance surveillance

Details

Title: Subtitle: Antimicrobial susceptibility of bacteria causing urinary tract infections in Latin American hospitals: results from the SENTRY Antimicrobial Surveillance Program (1997)
Creators: Helio S Sader
Ronald N Jones
Patricia L Winokur
Michael A Pfaller
Gary V Doern
Timothy Barrett
SENTRY Study Group, Latin America
Resource Type: Journal article
Publication Details: Clinical microbiology and infection, Vol.5(8), pp.478-487
Publisher: Blackwell Publishing Ltd
DOI: 10.1111/j.1469-0691.1999.tb00177.x
PMID: 11856291
ISSN: 1198-743X
eISSN: 1469-0691
Number of pages: 10
Language: English
Date published: 08/1999
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Medicine Administration; Internal Medicine
Record Identifier: 9984094723002771

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