Journal article
Antineutrophil cytoplasmic antibody? A useful serological marker for vasculitis
Journal of clinical immunology, Vol.11(4), pp.161-174
07/1991
DOI: 10.1007/BF00917422
PMID: 1918264
Abstract
Systemic necrotizing vasculitides, including polyarteritis nodosa, Churg-Strauss syndrome, "overlap" systemic vasculitis, Wegener's granulomatosis, and idiopathic crescentic glomerulonephritis, are frequent clinical diagnostic problems. These diseases have diverse presentations and are often rapidly progressive, causing irreversible injury to the vessels of the kidneys and lungs before effective immunosuppressive therapy is instituted. Even in their less fulminant forms, they are a cause of significant morbidity and mortality. Antineutrophil cytoplasmic antibody, a recently identified autoantibody, has a high sensitivity and specificity for this spectrum of diseases. The clinical and pathological similarities, the high frequency of antineutrophil cytoplasmic antibody expression, and the similar good response to immunosuppressive therapy suggest that these diseases may be linked by a common pathophysiological mechanism. Evidence is growing that antineutrophil cytoplasmic antibody plays a central role in this mechanism. A revision in the classification scheme of vasculitides to recognize that the polyarteritis group (polyarteritis nodosa, Churg-Strauss syndrome, and "overlap" systemic vasculitis), Wegener's granulomatosis, and idiopathic crescentic glomerulonephritis are closely related diseases may be warranted. The clinical and pathological features of systemic necrotizing vasculitides and the current knowledge concerning antineutrophil cytoplasmic antibodies are reviewed. © 1991 Plenum Publishing Corporation.
Details
- Title: Subtitle
- Antineutrophil cytoplasmic antibody? A useful serological marker for vasculitis
- Creators
- James A Goeken
- Resource Type
- Journal article
- Publication Details
- Journal of clinical immunology, Vol.11(4), pp.161-174
- DOI
- 10.1007/BF00917422
- PMID
- 1918264
- ISSN
- 0271-9142
- eISSN
- 1573-2592
- Language
- English
- Date published
- 07/1991
- Academic Unit
- Pathology
- Record Identifier
- 9984203945602771
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