Journal article
Antinociception after intracerebroventricular administration of naltrindole in the mouse
European journal of pharmacology, Vol.214(2), pp.273-276
1992
DOI: 10.1016/0014-2999(92)90129-R
PMID: 1325358
Abstract
Intracerebroventricular (i.c.v.) injection of the δ-opioid receptor antagonist naltrindole hydrochloride (2.2–22.2 nmol) in mice produced a dose-dependent increase in tail flick and hot plate latencies with respective ED
50 and 95% confidence limits of 10.6 (8.3–13.9) and 16.4 (9.2–62.3) nmol. This increase in response latencies was antagonized by 1 mg/kg s.c. naloxone or by i.c.v. coadministration of 1.4 nmol ICI-174,864, a selective peptidergic δ-receptor antagonist. Pretreatment 24 h earlier with the irreversible μ-receptor antagonist β-funaltrexamine (6 nmol i.c.v.) or 1 h earlier with the selective κ-receptor antagonist nor-binaltorphimine (100 nmol i.c.v.) did not attenuate the antinociceptive effects of naltrindole. These data indicate that high doses of naltrindole may have agonist activity at supraspinal δ-opioid receptors in the mouse.
Details
- Title: Subtitle
- Antinociception after intracerebroventricular administration of naltrindole in the mouse
- Creators
- Awilda Stapelfeld - Neurological Diseases Research, G.D. Searle & Co., Chicago, IL 60077, U.S.ADonna L Hammond - Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, U.S.AMichael F Rafferty - Neurological Diseases Research, G.D. Searle & Co., Chicago, IL 60077, U.S.A
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.214(2), pp.273-276
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-2999(92)90129-R
- PMID
- 1325358
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 1992
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984007194802771
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