Journal article
Antinociceptive effects of SC-39566, an opioid dipeptide arylalkylamide, in the Rhesus monkey
European journal of pharmacology, Vol.231(2), pp.281-285
1993
DOI: 10.1016/0014-2999(93)90461-P
PMID: 8095901
Abstract
This study evaluated the antinociceptive activity of an opioid dipeptide arylalkylamide, SC-39566 (2,6-dimethyl-L-tyrosinyl-D-alanyl-(3-phenyl-1-propyl)-amide), in the Rhesus monkey using the discrete trial, intermittent shock titration paradigm. I.m. administration of doses ranging from 12 to 24 mg/kg produced a dose-dependent increase in escape threshold and a dose-dependent rightward shift in the frequency distribution of responses to suprathreshold electrocutaneous stimuli. Although equivalent with respect to efficacy, SC-39566 was only one-fourth to one-sixth as potent as morophine in this paradigm. This study is the first report of the antinociceptive activity of an opioid dipeptide arylalkylamide after systematic admimistration in the primate.
Details
- Title: Subtitle
- Antinociceptive effects of SC-39566, an opioid dipeptide arylalkylamide, in the Rhesus monkey
- Creators
- Donna L Hammond - Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USAJames L Bloss - Department of Nervous System Diseases Research, G.D. Searle & Company, Skokie, IL 60077, USA
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.231(2), pp.281-285
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-2999(93)90461-P
- PMID
- 8095901
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 1993
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984006465002771
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