Journal article
Antioxidant Therapy Attenuates JNK Activation and Apoptosis in the Remote Noninfarcted Myocardium after Large Myocardial Infarction
Biochemical and biophysical research communications, Vol.280(1), pp.353-357
01/12/2001
DOI: 10.1006/bbrc.2000.4134
PMID: 11162522
Abstract
We hypothesized that the concomitant occurrence of increased oxidative stress, JNK activation, and myocyte apoptosis in the remote myocardium (RM) following a large myocardial infarction (MI) are causally related. Three days following coronary ligation, rats were randomized to treatment with probucol and PDTC (MI-T) or vehicle (MI). Control rats (C) underwent sham operation. At 7 weeks, TBARS assay showed increased level of lipid-peroxidation within the RM in the MI group vs C, which was completely inhibited in the MI-T group. Similarly, Western blot analysis showed a twofold increase in p-JNK in the MI group, vs C, which was attenuated in MI-T, a result confirmed by a JNK-kinase activity. Furthermore, apoptosis was increased within the RM in MI vs C, while this was inhibited in MI-T. We conclude that long-term antioxidant therapy with probucol and PDTC attenuates oxidative stress, JNK activation, and myocyte apoptosis within the RM after large MI.
Details
- Title: Subtitle
- Antioxidant Therapy Attenuates JNK Activation and Apoptosis in the Remote Noninfarcted Myocardium after Large Myocardial Infarction
- Creators
- Wei-Gen Li - University of IowaLawrence Coppey - University of IowaRobert M. Weiss - University of IowaHelgi J. Oskarsson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.280(1), pp.353-357
- Publisher
- Elsevier Inc
- DOI
- 10.1006/bbrc.2000.4134
- PMID
- 11162522
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Language
- English
- Date published
- 01/12/2001
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359915402771
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