Antioxidant use in Friedreich ataxia

Lauren Myers; Jennifer M Farmer; Robert B Wilson; Lisa Friedman; Amy Tsou; Susan L Perlman; Sub H Subramony; Christopher M Gomez; Tetsuo Ashizawa; George R Wilmot; Katherine D Mathews; Laura J Balcer; David R Lynch

doi:10.1016/j.jns.2007.10.008

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Journal article

Peer reviewed

Antioxidant use in Friedreich ataxia

Lauren Myers, Jennifer M Farmer, Robert B Wilson, Lisa Friedman, Amy Tsou, Susan L Perlman, Sub H Subramony, Christopher M Gomez, Tetsuo Ashizawa, George R Wilmot, …

Journal of the neurological sciences, Vol.267(1), pp.174-176

2008

DOI: 10.1016/j.jns.2007.10.008

PMCID: PMC2279016

PMID: 17988688

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Abstract

Many antioxidants have been suggested as potential treatments for Friedreich ataxia, but have not been tested in clinical trials. We found that a majority of patients in our cohort already use such antioxidants, including idebenone, which is not available at a pharmaceutical grade in the United States. Younger age, cardiomyopathy and shorter GAA repeat length were independent predictors of idebenone use, but no factors predicted use of other antioxidants. This confirms that non-prescription antioxidant use represents a major confounder to formal trials of existing and novel agents for Friedreich ataxia.

Ataxia

Cerebellum

Idebenone

Clinical trial

Details

Title: Subtitle: Antioxidant use in Friedreich ataxia
Creators: Lauren Myers - Department of Neurology, University of Pennsylvania School of Medicine, United States
Jennifer M Farmer - Department of Neurology, University of Pennsylvania School of Medicine, United States
Robert B Wilson - Children's Hospital of Philadelphia, Philadelphia, PA, 19104, United States
Lisa Friedman - Department of Neurology, University of Pennsylvania School of Medicine, United States
Amy Tsou - Department of Neurology, University of Pennsylvania School of Medicine, United States
Susan L Perlman - University of California Los Angeles, Los Angeles, CA, United States
Sub H Subramony - University of Mississippi, Jackson, MS, United States
Christopher M Gomez - University of Minnesota, Minneapolis, MN, United States
Tetsuo Ashizawa - University of Texas Medical Branch, Galveston, TX, United States
George R Wilmot - Emory University, Atlanta, GA, United States
Katherine D Mathews - University of Iowa, Iowa City, IA, United States
Laura J Balcer - Department of Neurology, University of Pennsylvania School of Medicine, United States
David R Lynch - Department of Neurology, University of Pennsylvania School of Medicine, United States
Resource Type: Journal article
Publication Details: Journal of the neurological sciences, Vol.267(1), pp.174-176
DOI: 10.1016/j.jns.2007.10.008
PMID: 17988688
PMCID: PMC2279016
NLM abbreviation: J Neurol Sci
ISSN: 0022-510X
eISSN: 1878-5883
Publisher: Elsevier B.V
Language: English
Date published: 2008
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984014022102771

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