Journal article
Antiphospholipid antibodies and subclinical interstitial lung disease in the MESA cohort
Respiratory research, Vol.26(1), 340
11/28/2025
DOI: 10.1186/s12931-025-03395-3
PMCID: PMC12664236
PMID: 41316278
Abstract
Interstitial lung disease (ILD) is a rare complication of antiphospholipid syndrome (APS), but circulating antiphospholipid antibodies have been detected in patients with ILD without APS. Whether antiphospholipid antibodies are associated with subclinical ILD phenotypes is unknown. We aim to examine the associations between anticardiolipin (aCL) and B-2 glycoprotein-1 (B2GP1) isotypes and high attenuation areas (HAA) and interstitial lung abnormalities (ILA) on CT scans in the Multi-Ethnic Study of Atherosclerosis (MESA).
We measured serum aCL and B2GP1 isotypes and calculated proportion of HAA on cardiac CT scan in 6623 MESA participants at baseline. The presence of ILAs were assessed on full lung CT scans at Exam 5. We used linear and logistic regression to examine these associations. We examined interactions by age, race, and smoking status.
In adjusted models, every doubling of aCL IgA, IgG, and IgM was associated with 0.36% (95% CI 0.03 to 0.70), 0.31% (95% CI 0.08 to 0.54), and 0.30% (95% CI 0.10 to 0.50) higher HAA in White participants, respectively. No association was found in participants of other races/ethnicities. Smoking modified the association between B2GP1 isotypes and HAA: in individuals with moderate smoking history, every doubling of B2GP1 IgA, IgG and IgM was associated with 0.84% (95% CI 0.30 to 1.38), 0.97% (95% CI 0.43 to 1.52) and 0.65% (95% CI 0.11 to 1.20) higher HAA, respectively. There was no association between antiphospholipid antibodies and ILA.
Antiphospholipid antibodies are associated with HAA, a quantitative measure of lung injury, inflammation and fibrosis.
Details
- Title: Subtitle
- Antiphospholipid antibodies and subclinical interstitial lung disease in the MESA cohort
- Creators
- Claire F McGroder - Columbia University Irving Medical CenterMary M Salvatore - Albert Einstein College of MedicineJohn Newell - University of IowaJubal Watts - University of Alabama at BirminghamP Hrudaya Nath - University of Alabama at BirminghamSushilkumar K Sonavane - Mayo ClinicEric A Hoffman - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA, USAGanesh Raghu - University of WashingtonR Graham Barr - Columbia University Irving Medical CenterJohn S Kim - University of VirginiaAnna J Podolanczuk - Cornell UniversityChristine Kim Garcia - Columbia University Irving Medical CenterElana J Bernstein - Columbia University Irving Medical Center
- Resource Type
- Journal article
- Publication Details
- Respiratory research, Vol.26(1), 340
- DOI
- 10.1186/s12931-025-03395-3
- PMID
- 41316278
- PMCID
- PMC12664236
- NLM abbreviation
- Respir Res
- ISSN
- 1465-9921
- eISSN
- 1465-993X
- Publisher
- Springer
- Grant note
- T32 HL105323 / NHLBI NIH HHS R01-HL-164758 / NHLBI NIH HHS K23-AR-075112 / NIAMS NIH HHS K23 HL140199 / NHLBI NIH HHS W81XWH2210163 / Congressionally Directed Medical Research Programs K23-HL-150301 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/28/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9985089134202771
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