Journal article
Antiresorptive Therapy to Reduce Fracture Risk and Effects on Dental Implant Outcomes in Patients With Osteoporosis:A Systematic Review and Osteonecrosis of the Jaw Taskforce Consensus Statement
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, Vol.31(5), pp.686-698
05/2025
DOI: 10.1016/j.eprac.2025.02.016
PMID: 40335186
Abstract
Objective: Placement of a dental implant in a patient on antiresorptive therapy has been hypothesized to increase the risk of medication-related osteonecrosis of the jaw (MRONJ) and/or impact implant survival. In patients with osteoporosis, the risk of MRONJ with antiresorptive therapy is only marginally higher than observed in the general population. Methods: The International ONJ Taskforce conducted a systematic review of the literature and evaluated the outcomes of implant placement in individuals with osteoporosis receiving antiresorptive therapy. Results: The data were reviewed by the International Taskforce, and consensus was achieved on the following GRADEd recommendation. In patients with osteoporosis on antiresorptive therapy, the Taskforce suggests that antiresorptive therapy does not need to be stopped prior to proceeding with dental implant (weak recommendation, very low-quality evidence). Long-term bisphosphonate use maybe associated with a small increase in the risk of MRONJ (3 cases per 1000 patients; adjusted hazard ratio: 4.09, 95% CI: 2.75-6.09, P <.001, moderate certainty). Conclusion: Current evidence does not suggest an association between antiresorptive therapy in patients with osteoporosis and dental implant failure. Implants may be safely placed in the presence of concomitant use of bisphosphonates or denosumab in patients with osteoporosis with no evidence of an increased risk of implant failure/compromise.
Details
- Title: Subtitle
- Antiresorptive Therapy to Reduce Fracture Risk and Effects on Dental Implant Outcomes in Patients With Osteoporosis:A Systematic Review and Osteonecrosis of the Jaw Taskforce Consensus Statement
- Creators
- Dalal S AliAliya A KhanArchibald MorrisonSotirios TetradisReza D MirzaMohamed El RabbanyBo AbrahamsenTara L AghalooHatim Al-AlwaniRana Al-DabaghAthanasios D AnastasilakisMohit BhandariJean Jacques BodyMaria Luisa BrandiRomina Brignardello-PetersenJacques P BrownAngela M CheungJuliet CompstonCyrus CooperAdolfo Diez-PerezSerge L FerrariGordon GuyattDavid HanleyNicholas C HarveyRobert G JosseDavid L KendlerSarah KhanSandra KimBente L LangdahlChristos MagopoulosBasel K MasriSarah L MorganSuzanne N MorinNicola NapoliBarbara Obermayer-PietschAndrea PalermoJessica PepeEdmund PetersDominique D PierrozRene RizzoliDeborah P SaundersClark M StanfordRiad SulimaniAkira TaguchiSakae TanakaNelson B WattsJoile ZamudioM. Carola ZillikensSalvatore L Ruggiero
- Resource Type
- Journal article
- Publication Details
- Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, Vol.31(5), pp.686-698
- DOI
- 10.1016/j.eprac.2025.02.016
- PMID
- 40335186
- NLM abbreviation
- Endocr Pract
- ISSN
- 1530-891X
- eISSN
- 1934-2403
- Publisher
- Elsevier; SAN DIEGO
- Grant note
- American Association of Oral and Maxillofacial Surgeons (AAOMS)Canadian Association of Oral and Maxillofacial Surgeons (CAOMS)Academy of Osteointegration, McMaster University calcium disorders clinic
We would like to acknowledge the following members of the ONJ Taskforce for their contributions to this work: Drs Khulod Almonaei, Farah Alsarraf, K. Shawn Davison, Akira Itabashi, Iman M'Hiri and Ethel Siris. We would also like to thank the following societies for endorsing this consensus statement: the American Society of Bone and Mineral Research (ASBMR) , the American Association of Oral and Maxillofacial Surgeons (AAOMS) , the Canadian Association of Oral and Maxillofacial Surgeons (CAOMS) , the Canadian Academy of Oral and Maxillofacial Pathology and Oral Medicine (CAOMPOM) , the European Calcified Tissue Society (ECTS) , and the International Osteoporosis Foundation (IOF) . Funding was received from the following associations: The American Association of Oral and Maxillofacial Surgeons (AAOMS) , The Canadian Association of Oral and Maxillofacial Surgeons (CAOMS) , and The Academy of Osteointegration, McMaster University calcium disorders clinic.
- Language
- English
- Date published
- 05/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Dentistry Administration; Prosthodontics; Craniofacial Anomalies Research Center
- Record Identifier
- 9984824295702771
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