Journal article
Antiretroviral drug resistance, HIV-1 tropism, and HIV-1 subtype among men who have sex with men with recent HIV-1 infection
AIDS (London), Vol.21(9), pp.1165-1174
2007
DOI: 10.1097/QAD.0b013e32810fd72e
PMID: 17502727
Abstract
Objective:
Antiretroviral drug treatment may be complicated in individuals infected with antiretroviral drug-resistant or non-subtype B HIV-1 strains. HIV-1 tropism may also affect disease progression. We analyzed antiretroviral drug resistance, HIV-1 subtype, and HIV-1 tropism among 195 men who have sex with men from six major cities in the United States, using samples collected within 6 months of HIV-1 seroconversion (1999–2003).
Methods:
HIV-1 genotyping was performed using the ViroSeq HIV-1 Genotyping System. HIV-1 tropism was determined using a commercial assay. HIV-1 subtyping was performed by phylogenetic analysis of pol region sequences.
Results:
Thirty-one (15.9%) of the men had evidence of antiretroviral drug resistance. Seven (3.6%) men had multi-class resistance, including three (1.5%) with resistance to all three antiretroviral drug classes. We found no statistically significant association of antiretroviral drug resistance with demographic factors, sexual practices, self-reported sexually transmitted infections, use of recreational drugs, or use of antiretroviral drug post-exposure prophylaxis. All samples were HIV-1 subtype B. Four men had CXCR4-using HIV-1 strains. One man with a CXCR4-using strain also had antiretroviral drug resistance.
Conclusions:
Antiretroviral drug resistance is relatively common among recently infected men who have sex with men in the United States. CXCR4-using strains were detected in a small number of these infections, which were all subtype B HIV-1.
Details
- Title: Subtitle
- Antiretroviral drug resistance, HIV-1 tropism, and HIV-1 subtype among men who have sex with men with recent HIV-1 infection
- Creators
- Susan H ESHLEMAN - Johns Hopkins University School of Medicine, Baltimore, Maryland, United StatesMaria HUSNIK - Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesBeryl KOBLIN - New York Blood Center, New York, New York, United StatesSarah HUDELSON - Johns Hopkins University School of Medicine, Baltimore, Maryland, United StatesDeborah DONNELL - Statistical Center for HIV/AIDS Research & Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesYijian Huang - Emory University, Atlanta, Georgia, United StatesWei Huang - Monogram Biosciences, South San Francisco, California, United StatesStephen HART - Frontier Science and Technology Research Foundation, Amherst, New York, United StatesBrooks JACKSON - Johns Hopkins University School of Medicine, Baltimore, Maryland, United StatesThomas COATES - University of California at Los Angeles, Los Angeles, California, United StatesMargaret CHESNEY - National Institutes of Health, Bethesda, Maryland, United States
- Resource Type
- Journal article
- Publication Details
- AIDS (London), Vol.21(9), pp.1165-1174
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1097/QAD.0b013e32810fd72e
- PMID
- 17502727
- ISSN
- 0269-9370
- eISSN
- 1473-5571
- Language
- English
- Date published
- 2007
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047622202771
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