Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus

Noah S Butler; Ajai A Dandekar; Stanley Perlman

doi:10.1128/JVI.01580-07

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Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus

Journal article

Open access

Peer reviewed

Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus

Noah S Butler, Ajai A Dandekar and Stanley Perlman

Journal of virology, Vol.81(24), pp.13291-13298

12/2007

DOI: 10.1128/JVI.01580-07

PMCID: PMC2168833

PMID: 17913802

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https://europepmc.org/articles/pmc2168833View

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Abstract

Mutation within virus-derived CD8 T-cell epitopes can effectively abrogate cytotoxic T-lymphocyte (CTL) recognition and impede virus clearance in infected hosts. These so-called "CTL escape variant viruses" are commonly selected during persistent infections and are associated with rapid disease progression and increased disease severity. Herein, we tested whether antiviral antibody-mediated suppression of virus replication and subsequent virus clearance were necessary for preventing CTL escape in coronavirus-infected mice. We found that compared to wild-type mice, B-cell-deficient mice did not efficiently clear infectious virus, uniformly developed clinical disease, and harbored CTL escape variant viruses. These data directly demonstrate a critical role for antiviral antibody in protecting from the selective outgrowth of CTL escape variant viruses.

T-Lymphocytes, Cytotoxic - immunology

Encephalomyelitis - mortality

Humans

Mice, Inbred C57BL

Epitopes, T-Lymphocyte - genetics

Coronavirus Infections - mortality

Coronavirus Infections - immunology

Murine hepatitis virus - immunology

Animals

Coronavirus Infections - virology

Animals, Suckling

Encephalomyelitis - immunology

Encephalomyelitis - prevention & control

Antibodies, Viral - immunology

Female

Mice

Mice, Inbred BALB C

Immunodominant Epitopes - genetics

Mutation

Murine hepatitis virus - genetics

Details

Title: Subtitle: Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus
Creators: Noah S Butler - Program in Immunology, University of Iowa, Iowa City, Iowa 52242, USA
Ajai A Dandekar
Stanley Perlman
Resource Type: Journal article
Publication Details: Journal of virology, Vol.81(24), pp.13291-13298
DOI: 10.1128/JVI.01580-07
PMID: 17913802
PMCID: PMC2168833
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: United States
Grant note: T32 AI007511 / NIAID NIH HHS NS36592 / NINDS NIH HHS F31 NS042981 / NINDS NIH HHS NS42981 / NINDS NIH HHS T32 GM007337 / NIGMS NIH HHS R01 NS036592 / NINDS NIH HHS
Language: English
Date published: 12/2007
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777470402771

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