Journal article
Anxiety independently contributes to elevated inflammation in humans with obesity
Obesity (Silver Spring, Md.), Vol.25(2), pp.286-289
02/2017
DOI: 10.1002/oby.21698
PMCID: PMC5269606
PMID: 28000423
Abstract
Objective
Anxious and depressive states are associated with increased cardiovascular disease (CVD) risk and a proinflammatory phenotype, although the latter appears to be at least partially explained by adiposity. It was hypothesized that depression and anxiety would be associated with elevated inflammation independent of adiposity in persons with obesity at high risk of CVD.
Methods
This study explored the relation between baseline anxiety as measured by the Beck Anxiety Inventory and depression as measured by the Beck Depression Inventory‐II and baseline serum c‐reactive protein (CRP) in a cross‐sectional sample of 100 participants [mean (SD) age 57.8 (7.7) years; 64% female] with obesity [mean (SD) body mass index, BMI 37.3 (5.5) kg/m2] enrolled in a clinical trial for pharmacological weight loss.
Results
Beck Anxiety Inventory, but not Beck Depression Inventory‐II, scores were significantly correlated with CRP (ρ = 0.28, P = 0.005). BMI was also highly correlated with CRP (ρ = 0.42, P < 0.0001). In multivariate models, the relation between anxiety and CRP remained significant (P = 0.038), independent of BMI, age, and sex.
Conclusions
Anxiety, but not depression, was associated with elevated inflammation in persons with obesity beyond that attributable to higher BMI. Further study is warranted to assess whether anxiety represents a potential therapeutic target to mitigate corresponding CVD risk associated with elevated inflammation in persons with obesity.
Details
- Title: Subtitle
- Anxiety independently contributes to elevated inflammation in humans with obesity
- Creators
- Gary L Pierce - The University of IowaGraziela Z Kalil - The University of IowaTiwaloluwa Ajibewa - The University of IowaSeth W Holwerda - The University of IowaJane Persons - The University of IowaDavid J Moser - The University of IowaJess G Fiedorowicz - The University of Iowa
- Resource Type
- Journal article
- Publication Details
- Obesity (Silver Spring, Md.), Vol.25(2), pp.286-289
- DOI
- 10.1002/oby.21698
- PMID
- 28000423
- PMCID
- PMC5269606
- NLM abbreviation
- Obesity (Silver Spring)
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- Number of pages
- 4
- Grant note
- American Heart Association (13SDG143400012) NIH Clinical and Translational Science Award (CTSA) (U54TR001356) NIMH (K23 MH083695) NHLBI (P01HL014388) National Institutes of Health (NIH) T32 Training (HL07121)
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Psychiatry; Epidemiology; Medicine Administration; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984002579002771
Metrics
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