Journal article
Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study
International journal of cardiology, Vol.331, pp.214-220
05/15/2021
DOI: 10.1016/j.ijcard.2021.02.017
PMCID: PMC8026709
PMID: 33587941
Abstract
The prevalence of abdominal aortic aneurysm is high in chronic obstructive pulmonary disease (COPD) population. Emphysema involves proteolytic destruction of elastic fibers. Therefore, emphysema may also contribute to thoracic aorta dilatation. This study assessed aorta dilation in smokers stratified by presence of COPD, emphysema and airway thickening.
Aorta diameters were measured on 3D magnetic resonance angiography in smokers recruited from the Multi-Ethnic Study of Atherosclerosis (MESA), the Emphysema and Cancer Action Project (EMCAP), and the local community. COPD was defined by standard spirometric criteria; emphysema was measured quantitatively on computed tomography and bronchitis was determined from medical history.
Participants (n = 315, age 58-79) included 150 with COPD and 165 without COPD, of whom 56% and 19%, respectively, had emphysema. Subjects in the most severe quartile of emphysematous change showed the largest diameter at all four aorta locations compared to those in the least severe quartiles (all p < 0.001). Comparing subjects with and without COPD, aorta diameters were larger in participants with severe COPD in ascending and arch (both p < 0.001), and abdominal aorta (p = 0.001). Chronic bronchitis and bronchial wall thickness did not correlate with aorta diameter. In subjects with emphysema, subjects with coexistence of COPD showed larger aorta than those without COPD in ascending (p = 0.003), arch (p = 0.002), and abdominal aorta (p = 0.04).
This study showed larger aorta diameter in subjects with COPD and severe emphysema compared to COPD related to chronic bronchitis or bronchial wall thickening.
Details
- Title: Subtitle
- Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study
- Creators
- Kana Fujikura - National Heart Lung and Blood InstituteAlessandra Albini - Columbia UniversityR Graham Barr - Columbia UniversityMegha Parikh - Columbia UniversityJulia Kern - Columbia UniversityEric Hoffman - University of IowaGrant T Hiura - Columbia UniversityDavid A Bluemke - University of Wisconsin–MadisonJames Carr - Northwestern UniversityJoão A C Lima - Johns Hopkins UniversityErin D Michos - Johns Hopkins UniversityAntoinette S Gomes - University of California, Los AngelesMartin R Prince - Weill Cornell Medicine
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology, Vol.331, pp.214-220
- DOI
- 10.1016/j.ijcard.2021.02.017
- PMID
- 33587941
- PMCID
- PMC8026709
- NLM abbreviation
- Int J Cardiol
- ISSN
- 0167-5273
- eISSN
- 1874-1754
- Grant note
- HHSN268200900017C / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS 75N92020D00006 / NHLBI NIH HHS 75N92020D00001 / NHLBI NIH HHS 75N92020D00002 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS HHSN268201500003C / NHLBI NIH HHS 75N92020D00005 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS 75N92020D00003 / NHLBI NIH HHS 75N92020D00007 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS 75N92020D00004 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS HHSN268201500003I / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS UL1 TR001079 / NCATS NIH HHS N01HC95165 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS UL1 TR001420 / NCATS NIH HHS
- Language
- English
- Date published
- 05/15/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318705002771
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