Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease

Katherine Osborne-Crowley; Sophie C Andrews; Izelle Labuschagne; Akshay Nair; Rachael  Scahill; David Craufurd; Sarah J Tabrizi; Julie C Stout; C Campbell; M Campbell; E Frajman; C Milchman; A O'Regan; A Coleman; R D Santos; J Decolongon; A Sturrock; E Bardinet; C Jauffret; D Justo; S Lehericy; C Marelli; K Nigaud; P Pourchot; R Valabregue; N Bechtel; S Bohlen; R Reilmann; A Hoffman; P Kraus; B Landwehrmeyer; SJA van den Bogaard; E M Dumas; J van der Grond; E P t'Hart; C Jurgens; M N Witjes-Ane; N Arran; J Callaghan; C Stopford; C Frost; R Jones; C Berna; H Crawford; N Fox; C Gibbard; N Hobbs; N Lahiri; I Malone; R Ordidge; G Owen; A Patel; T Pepple; J Read; M Say; D Whitehead; E Wild; S Keenan; D M Cash; S Hicks; C Kennard; T Acharya; E Axelson; H Johnson; D Langbehn; C Wang; S Lee; W Monaco; H Rosas; S Queller; K Whitlock; B Borowsky; A Tobin; TRACK-HD Investigators

doi:10.1017/S1355617718001224

Journal article

Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease

Katherine Osborne-Crowley, Sophie C Andrews, Izelle Labuschagne, Akshay Nair, Rachael Scahill, David Craufurd, Sarah J Tabrizi, Julie C Stout, C Campbell, M Campbell, …

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, Vol.25(5), pp.453-461

2019

DOI: 10.1017/S1355617718001224

PMCID: PMC6542690

PMID: 30767839

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/6542690View

Open Access

Abstract

Objectives: Previous research has demonstrated an association between emotion recognition and apathy in several neurological conditions involving fronto-striatal pathology, including Parkinson's disease and brain injury. In line with these findings, we aimed to determine whether apathetic participants with early Huntington's disease (HD) were more impaired on an emotion recognition task compared to non-apathetic participants and healthy controls. Methods: We included 43 participants from the TRACK-HD study who reported apathy on the Problem Behaviours Assessment - short version (PBA-S), 67 participants who reported no apathy, and 107 controls matched for age, sex, and level of education. During their baseline TRACK-HD visit, participants completed a battery of cognitive and psychological tests including an emotion recognition task, the Hospital Depression and Anxiety Scale (HADS) and were assessed on the PBA-S. Results: Compared to the non-apathetic group and the control group, the apathetic group were impaired on the recognition of happy facial expressions, after controlling for depression symptomology on the HADS and general disease progression (Unified Huntington's Disease Rating Scale total motor score). This was despite no difference between the apathetic and non-apathetic group on overall cognitive functioning assessed by a cognitive composite score. Conclusions: Impairment of the recognition of happy expressions may be part of the clinical picture of apathy in HD. While shared reliance on frontostriatal pathways may broadly explain associations between emotion recognition and apathy found across several patient groups, further work is needed to determine what relationships exist between recognition of specific emotions, distinct subtypes of apathy and underlying neuropathology. (JINS, 2019, 25, 453-461)

Details

Title: Subtitle: Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease
Creators: Katherine Osborne-Crowley - University College London
Sophie C Andrews - Monash University
Izelle Labuschagne - Australian Catholic University
Akshay Nair - University College London Hospitals NHS Foundation Trust
Rachael Scahill - University College London Hospitals NHS Foundation Trust
David Craufurd - Manchester Academic Health Science Centre
Sarah J Tabrizi - University College London Hospitals NHS Foundation Trust
Julie C Stout - Monash University
C Campbell
M Campbell
E Frajman
C Milchman
A O'Regan
A Coleman
R D Santos
J Decolongon
A Sturrock
E Bardinet
C Jauffret
D Justo
S Lehericy
C Marelli
K Nigaud
P Pourchot
R Valabregue
N Bechtel
S Bohlen
R Reilmann
A Hoffman
P Kraus
B Landwehrmeyer
SJA van den Bogaard
E M Dumas
J van der Grond
E P t'Hart
C Jurgens
M N Witjes-Ane
N Arran
J Callaghan
C Stopford
C Frost
R Jones
C Berna
H Crawford
N Fox
C Gibbard
N Hobbs
N Lahiri
I Malone
R Ordidge
G Owen
A Patel
T Pepple
J Read
M Say
D Whitehead
E Wild
S Keenan
D M Cash
S Hicks
C Kennard
T Acharya
E Axelson
H Johnson
D Langbehn
C Wang
S Lee
W Monaco
H Rosas
C Campbell
S Queller
K Whitlock
B Borowsky
A Tobin
TRACK-HD Investigators
Resource Type: Journal article
Publication Details: JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, Vol.25(5), pp.453-461
DOI: 10.1017/S1355617718001224
PMID: 30767839
PMCID: PMC6542690
NLM abbreviation: J Int Neuropsychol Soc
ISSN: 1469-7661
Language: English
Date published: 2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Iowa Neuroscience Institute; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
Record Identifier: 9984232146602771

Metrics

67 Record Views

9 Times Cited - Web of Science