Journal article
Apathy Is Related to Cognitive Control and Striatum Volumes in Prodromal Huntington’s Disease
Journal of the International Neuropsychological Society, Vol.25(5), pp.462-469
05/2019
DOI: 10.1017/S1355617719000067
PMCID: PMC6711382
PMID: 30806337
Abstract
Objectives: Apathy is a debilitating symptom of Huntington’s disease (HD) and manifests before motor diagnosis, making it an excellent therapeutic target in the preclinical phase of Huntington’s disease (prHD). HD is a neurological genetic disorder characterized by cognitive and motor impairment, and psychiatric abnormalities. Apathy is not well characterized within the prHD. In previous literature, damage to the caudate and putamen has been correlated with increased apathy in other neurodegenerative and movement disorders. The objective of this study was to determine whether apathy severity in individuals with prHD is related to striatum volumes and cognitive control. We hypothesized that, within prHD individuals, striatum volumes and cognitive control scores would be related to apathy. Methods: We constructed linear mixed models to analyze striatum volumes and cognitive control, a composite measure that includes tasks assessing with apathy scores from 797 prHD participants. The outcome variable for each model was apathy, and the independent variables for the four separate models were caudate volume, putamen volume, cognitive control score, and motor symptom score. We also included depression as a covariate to ensure that our results were not solely related to mood. Results: Caudate and putamen volumes, as well as measures of cognitive control, were significantly related to apathy scores even after controlling for depression. Conclusions: The behavioral apathy expressed by these individuals was related to regions of the brain commonly associated with isolated apathy, and not a direct result of mood symptoms. (JINS, 2019, 25, 462–469)
Details
- Title: Subtitle
- Apathy Is Related to Cognitive Control and Striatum Volumes in Prodromal Huntington’s Disease
- Creators
- Maria B Misiura - 1Department of Psychology, Georgia State University, Atlanta, GeorgiaJennifer Ciarochi - 2Neuroscience Institute, Georgia State University, Atlanta, GeorgiaJatin Vaidya - 3 University of Iowa Carver College of Medicine, Iowa City, IowaJeremy Bockholt - 3 University of Iowa Carver College of Medicine, Iowa City, IowaHans J Johnson - 3 University of Iowa Carver College of Medicine, Iowa City, IowaVince D Calhoun - 1Department of Psychology, Georgia State University, Atlanta, GeorgiaJane S Paulsen - 3 University of Iowa Carver College of Medicine, Iowa City, IowaJessica A Turner - 1Department of Psychology, Georgia State University, Atlanta, Georgia
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.25(5), pp.462-469
- DOI
- 10.1017/S1355617719000067
- PMID
- 30806337
- PMCID
- PMC6711382
- NLM abbreviation
- J Int Neuropsychol Soc
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Publisher
- Cambridge University Press; New York, USA
- Number of pages
- 8
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative; University College Courses
- Record Identifier
- 9984070297302771
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