Journal article
Apnea after awake-regional and general anesthesia in infants: The General Anesthesia compared to Spinal anesthesia (GAS) study: comparing apnea and neurodevelopmental outcomes, a randomized controlled trial
Anesthesiology (Philadelphia), Vol.123(1), pp.38-54
07/2015
DOI: 10.1097/ALN.0000000000000709
PMCID: PMC4626294
PMID: 26001033
Abstract
Background: Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia. Methods: Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apnea up to 12 h postoperatively. Apnea assessment was unblinded. Results:
Details
- Title: Subtitle
- Apnea after awake-regional and general anesthesia in infants: The General Anesthesia compared to Spinal anesthesia (GAS) study: comparing apnea and neurodevelopmental outcomes, a randomized controlled trial
- Creators
- Andrew J Davidson - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, AustraliaNeil S Morton - Academic Unit of Anaesthesia, Pain and Critical Care, University of Glasgow, Glasgow, United KingdomSarah J Arnup - Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Melbourne, Victoria, AustraliaJurgen C de Graaff - Department of Anaesthesia, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, the NetherlandsNicola Disma - Department of Anesthesia, Istituto Giannina Gaslini, Genoa, ItalyDavinia E Withington - Department of Anaesthesia, Montreal Children’s Hospital, Montreal, CanadaGeoff Frawley - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, AustraliaRodney W Hunt - Department of Paediatrics, University of Melbourne, Melbourne, Victoria, AustraliaPollyanna Hardy - National Perinatal Epidemiology Unit, Clinical Trials Unit, University of Oxford, Oxford, United KingdomMagda Khotcholava - Department of Anaesthesia, Ospedale Papa Giovanni XXIII, Bergamo, ItalyBritta S von Ungern Sternberg - Pharmacology, Pharmacy, Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, AustraliaNiall Wilton - Department of Paediatric Anaesthesia and Operating Rooms, Starship Children’s Hospital, Auckland District Health Board, Auckland, New ZealandPietro Tuo - Department of Anesthesia, Istituto Giannina Gaslini, Genoa, ItalyIda Salvo - Department of Anesthesiology & Paediatric Intensive Care, Ospedale Pediatrico ‘Vittore Buzzi’, Milan, ItalyGillian Ormond - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, AustraliaRobyn Stargatt - School of Psychological Science, La Trobe University, Melbourne, Victoria, AustraliaBruno Guido Locatelli - Department of Anaesthesia, Ospedale Papa Giovanni XXIII, Bergamo, ItalyMary Ellen McCann - Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MassachusettsGeneral Anesthesia compared to Spinal anesthesia consortium
- Contributors
- Denisa M Haret (Contributor) - University of Iowa, AnesthesiaStephen R Hays (Contributor) - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- Anesthesiology (Philadelphia), Vol.123(1), pp.38-54
- DOI
- 10.1097/ALN.0000000000000709
- PMID
- 26001033
- PMCID
- PMC4626294
- ISSN
- 0003-3022
- eISSN
- 1528-1175
- Language
- English
- Date published
- 07/2015
- Academic Unit
- Stead Family Department of Pediatrics; Anesthesia
- Record Identifier
- 9984006345002771
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