Journal article
Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis
Parasite immunology, Vol.46(5), e13036
05/2024
DOI: 10.1111/pim.13036
PMCID: PMC11141729
PMID: 38720445
Appears in UI Libraries Support Open Access
Abstract
Apolipoprotein E (ApoE) has been associated with several diseases including Parkinson's disease, Alzheimer's and multiple sclerosis. ApoE also has documented immunomodulatory functions. We investigated gene expression in circulating monocytes and in bone marrows of patients with visceral leishmaniasis (VL) living in an endemic area in Bihar, India, and contrasted these with control healthy subjects or other diagnostic bone marrows from individuals in the same region. Samples from VL patients were obtained prior to initiating treatment. Our study revealed significant upregulated expression of the apoE transcript in patients with VL. Furthermore, the levels of ApoE protein were elevated in serum samples of subjects with VL compared with healthy endemic controls. These observations may provide clues regarding the complex interactions between lipid metabolism and immunoregulation of infectious and inflammatory diseases.
Details
- Title: Subtitle
- Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis
- Creators
- Gulafsha Kausar - Banaras Hindu UniversityShashi B Chauhan - George Washington UniversityRitirupa Roy - Banaras Hindu UniversityShashi Kumar - Banaras Hindu UniversityChristian Engwerda - QIMR Berghofer Medical Research InstituteSusanne Nylen - Karolinska InstitutetRajiv Kumar - Banaras Hindu UniversityMary E Wilson - University of IowaShyam Sundar - Banaras Hindu University
- Resource Type
- Journal article
- Publication Details
- Parasite immunology, Vol.46(5), e13036
- Publisher
- Wiley
- DOI
- 10.1111/pim.13036
- PMID
- 38720445
- PMCID
- PMC11141729
- eISSN
- 1365-3024
- Grant note
- I01 BX001983 / BLRD VA I01 BX000536 / BLRD VA U19 AI074321 / NIAID NIH HHS
- Language
- English
- Date published
- 05/2024
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984624459802771
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