Apolipoprotein E-e4, Processing Speed, and White Matter Volume in a Genetically Enriched Sample of Midlife Adults

Rebecca E Ready; B Baran; M Chaudhry; K Schatz; J Gordon; R. M. C Spencer

doi:10.1177/1533317511421921

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Apolipoprotein E-e4, Processing Speed, and White Matter Volume in a Genetically Enriched Sample of Midlife Adults

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Apolipoprotein E-e4, Processing Speed, and White Matter Volume in a Genetically Enriched Sample of Midlife Adults

Rebecca E Ready, B Baran, M Chaudhry, K Schatz, J Gordon and R. M. C Spencer

American journal of Alzheimer's disease and other dementias, Vol.26(6), pp.463-468

09/2011

DOI: 10.1177/1533317511421921

PMID: 21937476

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10845549/pdf/10.1177_1533317511421921.pdfView

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Abstract

Healthy midlife children of a parent with Alzheimer's disease ([AD] N = 23; 9 male) participated in neuropsychological testing, and magnetic resonance imaging (MRI) of brain volumetrics were obtained. In all, 35% of the sample were apolipoprotein E (ApoE)-e4 positive (n = 8; 5 male). The ApoE-e4 group exhibited significantly slower performances on an executive function and processing speed measure and had less white matter volume than the non-ApoE-e4 group. Lesser white matter volume was significantly correlated with slower processing speed. Processing speed and changes in white matter volume might be indicators of preclinical decline in AD.

Details

Title: Subtitle: Apolipoprotein E-e4, Processing Speed, and White Matter Volume in a Genetically Enriched Sample of Midlife Adults
Creators: Rebecca E Ready - Department of Psychology, University of Massachusetts Amherst, MA, USA
B Baran - Department of Psychology, University of Massachusetts Amherst, MA, USA
M Chaudhry - Department of Psychology, University of Massachusetts Amherst, MA, USA
K Schatz - Department of Psychology, University of Massachusetts Amherst, MA, USA
J Gordon - Department of Psychology, University of Massachusetts Amherst, MA, USA
R. M. C Spencer - Department of Psychology, University of Massachusetts Amherst, MA, USA
Resource Type: Journal article
Publication Details: American journal of Alzheimer's disease and other dementias, Vol.26(6), pp.463-468
DOI: 10.1177/1533317511421921
PMID: 21937476
NLM abbreviation: Am J Alzheimers Dis Other Demen
ISSN: 1533-3175
eISSN: 1938-2731
Language: English
Date published: 09/2011
Academic Unit: Communication Sciences and Disorders; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065376102771

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