Apparent lower rates of streptococcal toxic shock syndrome and lower mortality in children with invasive group A streptococcal infections compared with adults

H D Davies; A Matlow; S R Scriver; P Schlievert; M Lovgren; J A Talbot; D E Low

doi:10.1097/00006454-199401000-00011

Back

Apparent lower rates of streptococcal toxic shock syndrome and lower mortality in children with invasive group A streptococcal infections compared with adults

Journal article

Peer reviewed

Apparent lower rates of streptococcal toxic shock syndrome and lower mortality in children with invasive group A streptococcal infections compared with adults

H D Davies, A Matlow, S R Scriver, P Schlievert, M Lovgren, J A Talbot and D E Low

The Pediatric infectious disease journal, Vol.13(1), pp.49-55

01/1994

DOI: 10.1097/00006454-199401000-00011

PMID: 8170732

View Online

Abstract

Since 1985 there have been worldwide reports of increases in severe invasive Group A streptococcal (IGAS) infections. We reviewed the charts of all children with IGAS infections (defined as isolation of Group A streptococcus from a normally sterile site) presenting to our institution over a 7-year period (January, 1985, to December, 1991) and the literature. Streptococcal toxic shock syndrome required hypotension and multisystem organ involvement. Twenty-four patients (mean age, 4.96 +/- 4.4 years) were identified with IGAS infection. One patient (presenting in 1989) met the criteria for probable streptococcal toxic shock syndrome and none died. Eight of 19 Group A streptococcal isolates tested were streptococcal pyrogenic exotoxin (SPE) A producers, most (90%) had the speC gene and all had the speB gene and produced the toxin. No M or T type predominated. The low rates of streptococcal toxic shock syndrome and fatalities among children with IGAS infection are consistent with other pediatric but not with adult series. The apparent differences in outcome of IGAS between children and adults were not explained by the virulence factors we examined and may warrant further investigation.

Shock, Septic - etiology

Humans

Shock, Septic - epidemiology

Child, Preschool

Streptococcal Infections - epidemiology

Infant

Male

Streptococcal Infections - mortality

Streptococcal Infections - genetics

Adolescent

Ontario - epidemiology

Adult

Female

Streptococcus pyogenes

Streptococcal Infections - complications

Child

Infant, Newborn

Details

Title: Subtitle: Apparent lower rates of streptococcal toxic shock syndrome and lower mortality in children with invasive group A streptococcal infections compared with adults
Creators: H D Davies - Division of Infectious Diseases, Hospital for Sick Children, Toronto, Ontario, Canada
A Matlow
S R Scriver
P Schlievert
M Lovgren
J A Talbot
D E Low
Resource Type: Journal article
Publication Details: The Pediatric infectious disease journal, Vol.13(1), pp.49-55
Publisher: United States
DOI: 10.1097/00006454-199401000-00011
PMID: 8170732
ISSN: 0891-3668
eISSN: 1532-0987
Language: English
Date published: 01/1994
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001124302771

Metrics

18 Record Views

47 Times Cited - Web of Science