Journal article
Application of the Milan System for Reporting Salivary Gland Cytopathology in pediatric patients: An international, multi-institutional study
Cancer cytopathology, Vol.130(5), pp.370-380
05/2022
DOI: 10.1002/cncy.22556
PMID: 35081269
Abstract
Pediatric salivary gland fine-needle aspiration (FNA) is uncommon with a higher frequency of inflammatory lesions and a small proportion of malignancies. This international, multi-institutional cohort evaluated the application of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and the risk of malignancy (ROM) for each diagnostic category.
Pediatric (0- to 21-year-old) salivary gland FNA specimens from 22 international institutions of 7 countries, including the United States, England, Italy, Greece, Finland, Brazil, and France, were retrospectively assigned to an MSRSGC diagnostic category as follows: nondiagnostic, nonneoplastic, atypia of undetermined significance (AUS), benign neoplasm, salivary gland neoplasm of uncertain malignant potential (SUMP), suspicious for malignancy (SM), or malignant. Cytology-histology correlation was performed where available, and the ROM was calculated for each MSRSGC diagnostic category.
The cohort of 477 aspirates was reclassified according to the MSRSGC as follows: nondiagnostic, 10.3%; nonneoplastic, 34.6%; AUS, 5.2%; benign neoplasm, 27.5%; SUMP, 7.5%; SM, 2.5%; and malignant, 12.4%. Histopathologic follow-up was available for 237 cases (49.7%). The ROMs were as follows: nondiagnostic, 5.9%; nonneoplastic, 9.1%; AUS, 35.7%; benign neoplasm, 3.3%; SUMP, 31.8%; SM, 100%; and malignant, 100%. Mucoepidermoid carcinoma was the most common malignancy (18 of 237; 7.6%), and it was followed by acinic cell carcinoma (16 of 237; 6.8%). Pleomorphic adenoma was the most common benign neoplasm (95 of 237; 40.1%).
The MSRSGC can be reliably applied to pediatric salivary gland FNA. The ROM of each MSRSGC category in pediatric salivary gland FNA is relatively similar to the ROM of each category in adult salivary gland FNA, although the reported rates for the different MSRSGC categories are variable across institutions.
Details
- Title: Subtitle
- Application of the Milan System for Reporting Salivary Gland Cytopathology in pediatric patients: An international, multi-institutional study
- Creators
- Zahra Maleki - Johns Hopkins HospitalCarla Saoud - Johns Hopkins HospitalKartik Viswanathan - Emory University Hospital MidtownIrem Kilic - Loyola University Medical CenterErkka Tommola - Fimlab (Finland)Daniel T Griffin - University of KentuckyAmer Heider - University of MichiganGianluigi Petrone - Università Cattolica del Sacro CuoreVickie Y Jo - Brigham and Women's HospitalBarbara A Centeno - Moffitt Cancer CenterMauro Saieg - AC Camargo HospitalPanagiota Mikou - Laiko General Hospital of AthensGuido Fadda - University of MessinaSyed Z Ali - Johns Hopkins HospitalIvana Kholová - Fimlab (Finland)Eva M Wojcik - Loyola University Medical CenterGüliz A Barkan - Loyola University Medical CenterDavid W Eisele - Johns Hopkins HospitalClaudio Bellevicine - University of Naples Federico IIElena Vigliar - University of Naples Federico IIAustin B Wiles - Virginia Commonwealth UniversityAlyaa Al-Ibraheemi - Boston Children's HospitalDerek B Allison - University of KentuckyGlen R Dixon - Informa HealthcareAshish Chandra - Guy's and St Thomas' NHS Foundation TrustJonathan M Walsh - Johns Hopkins HospitalZubair W Baloch - Hospital of the University of PennsylvaniaWilliam C Faquin - Massachusetts General HospitalJeffrey F Krane - University of California, Los AngelesEsther Diana Rossi - Università Cattolica del Sacro CuoreLiron Pantanowitz - University of MichiganGiancarlo Troncone - University of Naples Federico IIFabiano M Callegari - Universidade Federal de São PauloJerzy Klijanienko - Institut Curie
- Resource Type
- Journal article
- Publication Details
- Cancer cytopathology, Vol.130(5), pp.370-380
- DOI
- 10.1002/cncy.22556
- PMID
- 35081269
- NLM abbreviation
- Cancer Cytopathol
- ISSN
- 1934-662X
- eISSN
- 1934-6638
- Language
- English
- Date published
- 05/2022
- Academic Unit
- Pathology
- Record Identifier
- 9984294922402771
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