Applications of nanotechnology in 3D printed tissue engineering scaffolds

Noah Z Laird; Timothy M Acri; Jaidev L Chakka; Juliana C Quarterman; Walla I Malkawi; Satheesh Elangovan; Aliasger K Salem

doi:10.1016/j.ejpb.2021.01.018

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Applications of nanotechnology in 3D printed tissue engineering scaffolds

Journal article

Open access

Peer reviewed

Applications of nanotechnology in 3D printed tissue engineering scaffolds

Noah Z Laird, Timothy M Acri, Jaidev L Chakka, Juliana C Quarterman, Walla I Malkawi, Satheesh Elangovan and Aliasger K Salem

European journal of pharmaceutics and biopharmaceutics, Vol.161, pp.15-28

04/2021

DOI: 10.1016/j.ejpb.2021.01.018

PMCID: PMC7969465

PMID: 33549706

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Abstract

[Display omitted] Tissue engineering is an interdisciplinary field that aims to combine life sciences and engineering to create therapies that regenerate functional tissue. Early work in tissue engineering mostly used materials as inert scaffolding structures, but research has shown that constructing scaffolds from biologically active materials can help with regeneration by enabling cell-scaffold interactions or release of factors that aid in regeneration. Three-dimensional (3D) printing is a promising technique for the fabrication of structurally intricate and compositionally complex tissue engineering scaffolds. Such scaffolds can be functionalized with techniques developed by nanotechnology research to further enhance their ability to stimulate regeneration and interact with cells. Nanotechnological components, nanoscale textures, and microscale/nanoscale printing can all be incorporated into the manufacture of 3D printed scaffolds. This review discusses recent advancements in the merging of nanotechnology with 3D printed tissue engineering scaffolds, with a focus on applications of nanoscale components, nanoscale texture, and innovative printing techniques and the effects observed in vitro and in vivo.

3D printing

Nanoscale texture

Nanotechnology

Scaffold

Tissue engineering

Details

Title: Subtitle: Applications of nanotechnology in 3D printed tissue engineering scaffolds
Creators: Noah Z Laird - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA
Timothy M Acri - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA
Jaidev L Chakka - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA
Juliana C Quarterman - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA
Walla I Malkawi - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA
Satheesh Elangovan - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA
Aliasger K Salem - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: European journal of pharmaceutics and biopharmaceutics, Vol.161, pp.15-28
DOI: 10.1016/j.ejpb.2021.01.018
PMID: 33549706
PMCID: PMC7969465
NLM abbreviation: Eur J Pharm Biopharm
ISSN: 0939-6411
eISSN: 1873-3441
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000002, name: NIH
Language: English
Date published: 04/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Periodontics
Record Identifier: 9984216693102771

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