Journal article
Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer
Therapeutic delivery, Vol.8(9), pp.791-803
08/2017
DOI: 10.4155/tde-2017-0043
PMID: 28825397
Abstract
Chemoradiotherapy (CRT) plays a key role in the curative treatment of many human cancers. The full utility of this paradigm is often restricted by limitations of conventional drug delivery. Nanotherapeutics have demonstrated great potential to overcome many of these issues. The potential benefits of nanotherapeutics in CRT include improved therapeutic efficacy, decreased toxicity, enhanced real-time in vivo tumor imaging, and the translation of novel small molecule drugs or nucleic acid therapies. Additionally, nanomedicines and radiation therapy exert distinct and complementary effects on the tumor microenvironment which can further enhance therapeutic efficacy compared with either modality alone. In this review, we highlight specific clinical and preclinical examples which demonstrate the potential benefits of nanotherapeutics in CRT.
Details
- Title: Subtitle
- Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer
- Creators
- Joseph M Caster - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, 52242, USAAndrew Z Wang - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Therapeutic delivery, Vol.8(9), pp.791-803
- DOI
- 10.4155/tde-2017-0043
- PMID
- 28825397
- ISSN
- 2041-5990
- eISSN
- 2041-6008
- Language
- English
- Date published
- 08/2017
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984046831402771
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