Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease

Michael D Abramoff; Patrice E Fort; Ian C Han; K. Thiran Jayasundera; Elliott H Sohn; Thomas W Gardner

doi:10.1167/iovs.17-21873

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Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease

Journal article

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Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease

Michael D Abramoff, Patrice E Fort, Ian C Han, K. Thiran Jayasundera, Elliott H Sohn and Thomas W Gardner

Investigative Ophthalmology & Visual Science, Vol.59(1), pp.519-527

01/2018

DOI: 10.1167/iovs.17-21873

PMCID: PMC5786342

PMID: 29372250

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Abstract

The Early Treatment Diabetic Retinopathy Study (ETDRS) and other standardized classification schemes have laid a foundation for tremendous advances in the understanding and management of diabetic retinopathy (DR). However, technological advances in optics and image analysis, especially optical coherence tomography (OCT), OCT angiography (OCTa), and ultra-widefield imaging, as well as new discoveries in diabetic retinal neuropathy (DRN), are exposing the limitations of ETDRS and other classification systems to completely characterize retinal changes in diabetes, which we term diabetic retinal disease (DRD). While it may be most straightforward to add axes to existing classification schemes, as diabetic macular edema (DME) was added as an axis to earlier DR classifications, doing so may make these classifications increasingly complicated and thus clinically intractable. Therefore, we propose future research efforts to develop a new, comprehensive, and clinically useful classification system that will identify multimodal biomarkers to reflect the complex pathophysiology of DRD and accelerate the development of therapies to prevent vision-threatening DRD.

neurodegeneration

Retina

retina structural

biomarkers imaging

classification

diabetes functional

Details

Title: Subtitle: Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease
Creators: Michael D Abramoff - Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States
Patrice E Fort - Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States
Ian C Han - Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, United States
K. Thiran Jayasundera - Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States
Elliott H Sohn - Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, United States
Thomas W Gardner - Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States
Resource Type: Journal article
Publication Details: Investigative Ophthalmology & Visual Science, Vol.59(1), pp.519-527
DOI: 10.1167/iovs.17-21873
PMID: 29372250
PMCID: PMC5786342
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: The Association for Research in Vision and Ophthalmology
Alternative title: Classification of Vascular and Neural Aspects of DR
Language: English
Date published: 01/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
Record Identifier: 9983806384702771

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