Journal article
Approach to tapering antisarcoidosis therapy
Current opinion in pulmonary medicine, Vol.25(5), pp.526-532
09/01/2019
DOI: 10.1097/MCP.0000000000000607
PMID: 31365387
Abstract
Purpose of review Sarcoidosis is a multisystemic granulomatous disease, which commonly affects the lung. The natural course of the disease and prognosis are variable from asymptomatic, spontaneous remission to progressive disease, which requires treatment. Once treatment is initiated, tapering therapy can be problematic. Recent findings Corticosteroids are recommended as first-line therapy, but optimal regimen and duration of treatment is not well established. Treatment may differ based on severity of disease, extrapulmonary involvement, physician and patient preferences. We reviewed currently recommended regimens, particularly, in pulmonary sarcoidosis and the use of alternative treatments as corticosteroid-sparing agents. Corticosteroid use is quite effective as initial therapy but is associated with significant side effects. An approach to tapering sarcoidosis therapy is not standardized, given the lack of evidence-based data. This review provides guidance based on the current literature.
Details
- Title: Subtitle
- Approach to tapering antisarcoidosis therapy
- Creators
- Kamonpun Ussavarungsi - University of IowaAlicia K. Gerke - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current opinion in pulmonary medicine, Vol.25(5), pp.526-532
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MCP.0000000000000607
- PMID
- 31365387
- ISSN
- 1070-5287
- eISSN
- 1531-6971
- Number of pages
- 7
- Grant note
- R01FD005993 / FOOD AND DRUG ADMINISTRATION; United States Department of Health & Human Services R01-FD005993 / Federal Drug Association (FDA)
- Language
- English
- Date published
- 09/01/2019
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359583902771
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