Journal article
Apurinic/Apyrmidinic Endonuclease 1 Regulates Endothelial NO Production and Vascular Tone
Circulation research, Vol.95(9), pp.902-910
10/29/2004
DOI: 10.1161/01.RES.0000146947.84294.4C
PMID: 15472121
Abstract
The dual-function protein apurinic/apyrmidinic endonuclease/redox factor-1 (APE1/ref-1) is essential for DNA repair and also governs the reductive activation of many redox-sensitive transcription factors. We examined the role of APE1/ref-1 in regulation of endothelium-dependent tone and systemic blood pressure. APE1/ref-1 mice have impaired endothelium-dependent vasorelaxation, reduced vascular NO levels, and are hypertensive. APE1/ref-1 upregulates H-ras expression and leads to H-ras–mediated, phosphoinositide-3 kinase/Akt kinase–dependent calcium sensitization of endothelial NO synthase (eNOS), stimulating NO production. The reducing property of APE1/ref-1 is essential for upregulation of H-ras and for the calcium sensitization of eNOS. These findings uncover a novel physiological role for APE1/ref-1 in regulating vascular tone by governance of eNOS activity and bioavailable NO.
Details
- Title: Subtitle
- Apurinic/Apyrmidinic Endonuclease 1 Regulates Endothelial NO Production and Vascular Tone
- Creators
- Byeong Jeon - From the Division of Cardiology, Department of Medicine (B.H.J., Y.C.P., B.Q., A.H., F.A.K., Y.-X.L., K.I.) and Department of Anesthesiology (G.G., A.R.W., D.E.B.), Johns Hopkins University School of Medicine, Baltimore, Md; Departments of Physiology (B.H.J.) and Pathology (J.-M.K.), Chungnam National University, Daejon, South Korea; Department of Microbiology and Immunology (Y.C.P.), Pusan National University, South Korea; and Department of Surgery (M.O.), Hokkaido University, Sapporo, JapanGaurav GuptaYoung ParkBing QiAzeb HaileFirdous KhandayYan-Xia LiuJin-Man KimMichitaka OzakiAnthony WhiteDan BerkowitzKaikobad Irani
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.95(9), pp.902-910
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.0000146947.84294.4C
- PMID
- 15472121
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 10/29/2004
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984047857302771
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