Journal article
Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Sizes III and V in Glaucoma and NAION
Translational vision science & technology, Vol.13(12), 15
12/02/2024
DOI: 10.1167/tvst.13.12.15
PMCID: PMC11645746
PMID: 39666357
Abstract
Disorders of the anterior optic nerve cause quantifiable patterns, or archetypes (AT), in visual fields (VFs) obtained using standardized automated perimetry using stimulus size III (size III). VFs with stimulus size V (size V) can reduce retest variability in eyes with moderate to severe loss. We postulated that VF testing using both stimuli would show similar ATs in eyes with glaucoma and nonarteritic anterior ischemic optic neuropathy (NAION).
We used 1969 same-day pairs of 24-2 size III and size V VFs from two datasets. QRK207 is the largest NAION study to date, and the VIPII study measured same-day VFs across many stimulus sizes. We censored raw sensitivities of less than 21 dB for size III and 24 dB for size V and age-standardized to total deviations, before archetypal analysis (AA). We compared the ATs between the two stimuli and the combined data.
Using 14 ATs for both glaucoma and NAION, AA captured similar patterns between the two stimuli in both diseases with 87% of AT pairings having a cosine similarity of 0.8 or greater. The combined ATs retained the patterns in the separate stimuli VFs.
AA shows that size V VFs provide quantifiable patterns of loss similar to size III. This aids in comparing stimulus sizes for monitoring VF patterns in disease progression.
AA shows similar quantifiable patterns of VF loss with size III or size V, supporting the use of size V to monitor eyes with moderate to severe VF loss.
Details
- Title: Subtitle
- Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Sizes III and V in Glaucoma and NAION
- Creators
- David Szanto - Icahn School of Medicine at Mount SinaiMichael Wall - University of IowaLuke X Chong - Deakin UniversityBrian Woods - University Hospital GalwayTobias Elze - Harvard Medical SchoolJui-Kai Wang - University of IowaMona Garvin - University of IowaRandy Kardon - University of IowaMark J Kupersmith - Icahn School of Medicine at Mount Sinai
- Resource Type
- Journal article
- Publication Details
- Translational vision science & technology, Vol.13(12), 15
- DOI
- 10.1167/tvst.13.12.15
- PMID
- 39666357
- PMCID
- PMC11645746
- NLM abbreviation
- Transl Vis Sci Technol
- ISSN
- 2164-2591
- eISSN
- 2164-2591
- Publisher
- ASSOC RESEARCH VISION OPHTHALMOLOGY INC
- Grant note
- New York Eye and Ear Infirmary Foundation, New York, NY: NEI EY032522 Research to Prevent Blindness, Inc., New York, NYShulman Family NAION Fund at Icahn School of Medicine at Mount SinaiNIH: P30 EY003790 Health Research Board: ICAT-2022-001 Irish Clinical Academic Training (ICAT) Programme
Supported by The New York Eye and Ear Infirmary Foundation, New York, NY; NEI EY032522; Research to Prevent Blindness, Inc., New York, NY; an unrestricted grant to the Department of Ophthalmology; Shulman Family NAION Fund at Icahn School of Medicine at Mount Sinai, NIH P30 EY003790, The Health Research Board (ICAT-2022-001) ; and the Irish Clinical Academic Training (ICAT) Programme.
- Language
- English
- Date published
- 12/02/2024
- Academic Unit
- Neurology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9984757156102771
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