Journal article
Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Size III and Size Modulation Perimetry in Glaucoma
Translational vision science & technology, Vol.14(10), 12
10/01/2025
DOI: 10.1167/tvst.14.10.12
PMCID: PMC12524828
PMID: 41071033
Abstract
Optic nerve disorders produce identifiable visual field (VF) patterns. Size modulation perimetry (SMP) unlike standard automated perimetry (SAP) shows little degradation of retest variability with increasing VF damage. We hypothesize that VF testing with stimulus size III (size III) and SMP would reveal analogous patterns, supporting interchangeability in clinical practice.
We analyzed 274 same-day pairs of VFs from 83 eyes of patients with glaucoma. Participants underwent testing every 6 months using size III and SMP VFs. We converted raw sensitivity data to total deviation (TD) scores relative to normative datasets, censoring size III sensitivities below 20 decibels (dB). Archetypal analysis (AA) was applied separately to each modality to identify characteristic VF patterns, or archetypes (ATs). We evaluated both absolute VF patterns and longitudinal VF changes by subtracting baseline measurements. Cosine similarity measured the overlap between ATs in size III and SMP.
Absolute size III and SMP VFs exhibited overlapping patterns, with 95% of ATs demonstrating a cosine similarity of ≥0.50. Change ATs showed lower similarity scores (30% with cosine similarity ≥0.50). However, some ATs still revealed similar underlying defects.
AA consistently extracted comparable VF defect patterns from size III and SMP in glaucoma. Absolute size III patterns closely aligned with SMP, whereas patterns of change showed partial agreement.
These findings suggest that SAP and SMP capture similar patterns of VF loss.
Details
- Title: Subtitle
- Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Size III and Size Modulation Perimetry in Glaucoma
- Creators
- David Szanto - Stony Brook SchoolEdward Linton - University of IowaMichael Wall - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Translational vision science & technology, Vol.14(10), 12
- DOI
- 10.1167/tvst.14.10.12
- PMID
- 41071033
- PMCID
- PMC12524828
- NLM abbreviation
- Transl Vis Sci Technol
- ISSN
- 2164-2591
- eISSN
- 2164-2591
- Publisher
- Association for Research in Vision and Ophthalmology
- Grant note
- Administration, Office of Research and DevelopmentBarry Family Center for Ophthalmic Artificial Intelligence and Human Health
Supported by a VA Merit Review Grant 5 I01 RX000140-03, and by an unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness, New York, NY, USA; the New York Eye and Ear Infirmary Foundation, New York, NY; the Shulman Family NAION Fund, New York, NY; the Neuro-Ophthalmology Research Fund of New York Eye and Ear Infirmary, New York, NY; the Research to Prevent Blindness, Inc., New York, NY, with an unrestricted grant to the Department of Ophthalmology; NEI R01 EY015473; Department of Veterans Affairs (VA) Center for the Prevention and Treatment of Visual Loss, Rehabilitation Research and Development (RR&D) I50 RX003002; VA RR&D I01RX003797; and 5IK1RX005029. This material is based upon work supported (or supported in part) by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government. The Barry Family Center for Ophthalmic Artificial Intelligence and Human Health.r Administration, Office of Research and Development. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government. The Barry Family Center for Ophthalmic Artificial Intelligence and Human Health.
- Language
- English
- Date published
- 10/01/2025
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9985014871302771
Metrics
10 Record Views