Are Vitamin D Levels Related to Sarcopenia in Children with Inflammatory Bowel Disease?

Sevim Cakar; Gulin Eren; Cahit Baris Erdur; Mehmet Onder; Safak Pelek; Duygu Demirtas; Ozlem Bekem; Cigdem Omur Ecevit

doi:10.3390/jcm14051548

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Are Vitamin D Levels Related to Sarcopenia in Children with Inflammatory Bowel Disease?

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Are Vitamin D Levels Related to Sarcopenia in Children with Inflammatory Bowel Disease?

Sevim Cakar, Gulin Eren, Cahit Baris Erdur, Mehmet Onder, Safak Pelek, Duygu Demirtas, Ozlem Bekem and Cigdem Omur Ecevit

Journal of clinical medicine, Vol.14(5), p.1548

03/01/2025

DOI: 10.3390/jcm14051548

PMID: 40095479

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Abstract

Background: Data on the impacts of vitamin D deficiency on sarcopenia in pediatric patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are lacking. We aimed to investigate the relationships between vitamin D levels and sarcopenia in patients with newly diagnosed IBD. Methods: A cross-sectional, retrospective study was conducted in a tertiary care children's hospital. Pediatric IBD patients who underwent magnetic resonance (MR) enteroclysis at the time of initial diagnosis were included. Total psoas muscle area (tPMA) at the L4/L5 intervertebral level was demonstrated on MR by scanning the right and left psoas muscle areas. Sarcopenia was defined as a measurement under the 10th percentile according to MR-derived reference values of tPMA percentile charts for healthy children aged 1-18 years. Vitamin D insufficiency was defined as a serum 25-OH-D level below 30 ng/mL and deficiency as that below 20 ng/mL. Collected data from demographic evaluation, clinic, and laboratory tests were statistically assessed. Results: According to the MR-derived reference values of tPMA, 85% (n = 33) of UC and 81% (n = 21) of CD patients had sarcopenia. The severe vitamin D deficiency ratio was 35.9% (n = 14) in UC and 38.5% (n = 10) in CD. We found that vitamin D levels were similar in patients with UC and CD, while they were significantly lower in the group below the 3rd percentile of tPMA (n = 41, median 9.8) than in the group between the 3rd and 10th percentiles (n = 13, median 16.9; p = 0.038). Conclusions: Formulating strategies to recognize and prevent sarcopenia, including the prevention and-if necessary-the treatment of vitamin D deficiency, could bring multi-faceted benefits.

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

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Title: Subtitle: Are Vitamin D Levels Related to Sarcopenia in Children with Inflammatory Bowel Disease?
Creators: Sevim Cakar - Dokuz Eylül University
Gulin Eren - Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
Cahit Baris Erdur - Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
Mehmet Onder - Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
Safak Pelek - Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
Duygu Demirtas - Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
Ozlem Bekem - Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
Cigdem Omur Ecevit - Univ Hlth Sci Dr Behcet Uz Childrens Hosp, Dept Pediat, Div Pediat Gastroenterol, TR-35210 Izmir, Turkiye
Resource Type: Journal article
Publication Details: Journal of clinical medicine, Vol.14(5), p.1548
DOI: 10.3390/jcm14051548
PMID: 40095479
NLM abbreviation: J Clin Med
ISSN: 2077-0383
eISSN: 2077-0383
Publisher: Mdpi
Number of pages: 10
Language: English
Date published: 03/01/2025
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9985217818402771

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