Journal article
Are individual-level risk factors for gastroschisis modified by neighborhood-level socioeconomic factors?
Birth defects research, Vol.115(15), pp.1438-1449
09/01/2023
DOI: 10.1002/bdr2.2224
PMCID: PMC10527855
PMID: 37439400
Abstract
Background: Two strong risk factors for gastroschisis are young maternal age (<20 years) and low/normal pre-pregnancy body mass index (BMI), yet the reasons remain unknown. We explored whether neighborhood-level socioeconomic position (nSEP) during pregnancy modified these associations.Methods: We analyzed data from 1269 gastroschisis cases and 10,217 controls in the National Birth Defects Prevention Study (1997-2011). To characterize nSEP, we applied the neighborhood deprivation index and used generalized estimating equations to calculate odds ratios and relative excess risk due to interaction.Results: Elevated odds of gastroschisis were consistently associated with young maternal age and low/normal BMI, regardless of nSEP. High-deprivation neighborhoods modified the association with young maternal age. Infants of young mothers in high-deprivation areas had lower odds of gastroschisis (adjusted odds ratio [aOR]: 3.1, 95% confidence interval [CI]: 2.6, 3.8) than young mothers in low-deprivation areas (aOR: 6.6; 95% CI: 4.6, 9.4). Mothers of low/normal BMI had approximately twice the odds of having an infant with gastroschisis compared to mothers with overweight/obese BMI, regardless of nSEP (aOR range: 1.5-2.3).Conclusion: Our findings suggest nSEP modified the association between gastroschisis and maternal age, but not BMI. Further research could clarify whether the modification is due to unidentified biologic and/or non-biologic factors.
Details
- Title: Subtitle
- Are individual-level risk factors for gastroschisis modified by neighborhood-level socioeconomic factors?
- Creators
- Dayna T. L. Neo - University of North Carolina at Chapel HillChantel L. L. Martin - University of North Carolina at Chapel HillSuzan L. Carmichael - Stanford UniversityMuge M. Gucsavas-Calikoglu - Univ North Carolina Chapel Hill, Sch Med, Dept Pediat, Div Genet & Metab, Chapel Hill, NC USAKristin M. Conway - University of IowaShannon Pruitt L. Evans - National Center on Birth Defects and Developmental DisabilitiesMarcia L. M. Feldkamp - University of UtahSuzanne M. Z. Gilboa - National Center on Birth Defects and Developmental DisabilitiesTabassum Z. I. Insaf - New York State Department of HealthFadi I. M. Musfee - University of Arkansas for Medical SciencesGary M. Shaw - Stanford UniversityCharles M. Shumate - Texas Department of State Health ServicesMartha M. F. Werler - Boston UniversityAndrew F. A. Olshan - University of North Carolina at Chapel HillTania A. Desrosiers - University of North Carolina at Chapel HillNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Birth defects research, Vol.115(15), pp.1438-1449
- DOI
- 10.1002/bdr2.2224
- PMID
- 37439400
- PMCID
- PMC10527855
- NLM abbreviation
- Birth Defects Res
- ISSN
- 2472-1727
- eISSN
- 2472-1727
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Language
- English
- Date published
- 09/01/2023
- Academic Unit
- Epidemiology
- Record Identifier
- 9984627191902771
Metrics
17 Record Views