Journal article
Area postrema, lateral parabrachial nucleus, and the antinatriorexic effect of bombesin
Peptides (New York, N.Y. : 1980), Vol.19(8), pp.1399-1406
1998
DOI: 10.1016/S0196-9781(98)00099-0
PMID: 9809655
Abstract
Bombesin (BN) injected to sodium depleted rats either centrally, particularly into the paraventricular nucleus (PVN) or peripherally by intraperitoneal (IP) route, exerts a potent inhibitory effect on the intake of 2% sodium chloride. To determine whether the area postrema (AP) and the lateral parabrachial nucleus (LPBN), which are known to be involved in the control of ingestive behavior, could be sites for the antinatiorexic activity of BN, we studied the effects of injections of this peptide into the LPBN or, by IP or fourth ventricular route, to surgically AP-lesioned rats. We observed that in sodium depleted rats: 1) injected into the LPBN at a dose of 50, but not of 25, ng per nucleus, BN significantly reduced the intake of 2% sodium chloride; 2) administered either intraperitoneally or into the fourth brain ventricle, BN induced a potent antinatriorexic effect in AP-sham lesioned animals; and 3) in the same experimental conditions, surgical ablation of the AP did not reduce the antinatriorexic effect of the peptide. These data indicate that the LPBN may be, with the PVN, a site for the BN-ergic inhibitory control of salt appetite and that the AP, which has been implicated in BN-induced anorexia, does not play a role in the antinatriorexic effect of this peptide.
Details
- Title: Subtitle
- Area postrema, lateral parabrachial nucleus, and the antinatriorexic effect of bombesin
- Creators
- G de Caro - Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, ItalyC Polidori - Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, ItalyT.G Beltz - Department of Psychology, University of Iowa, Iowa City, Iowa 52242-1407, USAA.K Johnson - Department of Psychology, University of Iowa, Iowa City, Iowa 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- Peptides (New York, N.Y. : 1980), Vol.19(8), pp.1399-1406
- DOI
- 10.1016/S0196-9781(98)00099-0
- PMID
- 9809655
- NLM abbreviation
- Peptides
- ISSN
- 0196-9781
- eISSN
- 1873-5169
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1998
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213275302771
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