Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients

Thida Win; Benjamin A. Thomas; Tryphon Lambrou; Brian F. Hutton; Nicholas J. Screaton; Joanna C. Porter; Toby M. Maher; Raymondo Endozo; Robert I. Shortman; Asim Afaq; Pauline Lukey; Peter J. Ell; Ashley M. Groves

doi:10.1007/s00259-013-2514-8

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Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients

Journal article

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Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients

Thida Win, Benjamin A. Thomas, Tryphon Lambrou, Brian F. Hutton, Nicholas J. Screaton, Joanna C. Porter, Toby M. Maher, Raymondo Endozo, Robert I. Shortman, Asim Afaq, …

European journal of nuclear medicine and molecular imaging, Vol.41(2), pp.337-342

02/01/2014

DOI: 10.1007/s00259-013-2514-8

PMCID: PMC3890564

PMID: 23942907

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Abstract

Patients with idiopathic pulmonary fibrosis (IPF) show increased PET signal at sites of morphological abnormality on high-resolution computed tomography (HRCT). The purpose of this investigation was to investigate the PET signal at sites of normal-appearing lung on HRCT in IPF. Consecutive IPF patients (22 men, 3 women) were prospectively recruited. The patients underwent F-18-FDG PET/HRCT. The pulmonary imaging findings in the IPF patients were compared to the findings in a control population. Pulmonary uptake of F-18-FDG (mean SUV) was quantified at sites of morphologically normal parenchyma on HRCT. SUVs were also corrected for tissue fraction (TF). The mean SUV in IPF patients was compared with that in 25 controls (patients with lymphoma in remission or suspected paraneoplastic syndrome with normal PET/CT appearances). The pulmonary SUV (mean +/- SD) uncorrected for TF in the controls was 0.48 +/- 0.14 and 0.78 +/- 0.24 taken from normal lung regions in IPF patients (p < 0.001). The TF-corrected mean SUV in the controls was 2.24 +/- 0.29 and 3.24 +/- 0.84 in IPF patients (p < 0.001). IPF patients have increased pulmonary uptake of F-18-FDG on PET in areas of lung with a normal morphological appearance on HRCT. This may have implications for determining disease mechanisms and treatment monitoring.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Areas of normal pulmonary parenchyma on HRCT exhibit increased FDG PET signal in IPF patients
Creators: Thida Win - Lister Hospital
Benjamin A. Thomas - University College London
Tryphon Lambrou - University College London
Brian F. Hutton - University College London
Nicholas J. Screaton - Papworth Hospital
Joanna C. Porter - University College London
Toby M. Maher - Royal Brompton Hospital
Raymondo Endozo - University College London
Robert I. Shortman - University College London
Asim Afaq - University College London
Pauline Lukey - GlaxoSmithKline
Peter J. Ell - University College London
Ashley M. Groves - University College London
Resource Type: Journal article
Publication Details: European journal of nuclear medicine and molecular imaging, Vol.41(2), pp.337-342
DOI: 10.1007/s00259-013-2514-8
PMID: 23942907
PMCID: PMC3890564
NLM abbreviation: Eur J Nucl Med Mol Imaging
ISSN: 1619-7070
eISSN: 1619-7089
Publisher: Springer Nature
Number of pages: 6
Grant note: 16463 / Cancer Research UK UK's Department of Health's NIHR Biomedical Research Centre
Language: English
Date published: 02/01/2014
Academic Unit: Radiology
Record Identifier: 9984318693102771

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