Journal article
Arginine Vasopressin Response to an Osmotic Stimulus in the Fetal Sheep
Pediatric research, Vol.12(1), pp.35-38
01/1978
DOI: 10.1203/00006450-197801000-00009
PMID: 643374
Abstract
Baseline plasma osmolality (pOsm) and plasma arginine vasopressin (pAVP) were measured in chronically catheterized fetal sheep. Mean baseline pAVP in fetuses from 101-120 days was 1.9 +/- 0.46 muU/ml (mean +/- SEM) with a pOsm of 293 +/- 1.8 mOsm/kg. In fetuses of 121-141 days of gestation, mean pAVP was significantly lower, 0.77 +/- 0.19 muU/ml (P less than 0.05), with a similar pOsm (293 +/- 1.9 mOsm/kg). The logarithmic baseline pAVP values were linearly correlated with pOsm for both groups. Hypertonic saline infusion resulted in a similar increase in the log pAVP corrected for the rise in pOsm in the 101-120-day fetuses and in 121-141-day fetuses. The slope of this response was similar to that of the steady state relationship. The data indicates that the fetal osmoreceptor system for control of arginine vasopressin secretion is fully functional in the last trimester of pregnancy.
Details
- Title: Subtitle
- Arginine Vasopressin Response to an Osmotic Stimulus in the Fetal Sheep
- Creators
- Richard E Weitzman - UCLA Medical CenterDelbert A Fisher - UCLA Medical CenterJean Robillard - University of IowaAllan Erenberg - UCLA Medical CenterRoland Kennedy - UCLA Medical CenterFred Smith - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.12(1), pp.35-38
- DOI
- 10.1203/00006450-197801000-00009
- PMID
- 643374
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 4
- Language
- English
- Date published
- 01/1978
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984773400702771
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