Journal article
Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis
Proceedings of the National Academy of Sciences - PNAS, Vol.113(48), pp.13881-13886
11/29/2016
DOI: 10.1073/pnas.1611283113
PMCID: PMC5137683
PMID: 27872285
Abstract
The "Beijing" Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has been associated with accelerated disease progression and increased antibiotic resistance. Here we performed a phylodynamic reconstruction of one of the L2 sublineages, the central Asian clade (CAC), which has recently spread to western Europe. We find that recent historical events have contributed to the evolution and dispersal of the CAC. Our timing estimates indicate that the clade was likely introduced to Afghanistan during the 1979-1989 Soviet-Afghan war and spread further after population displacement in the wake of the American invasion in 2001. We also find that drug resistance mutations accumulated on a massive scale in Mtb isolates from former Soviet republics after the fall of the Soviet Union, a pattern that was not observed in CAC isolates from Afghanistan. Our results underscore the detrimental effects of political instability and population displacement on tuberculosis control and demonstrate the power of phylodynamic methods in exploring bacterial evolution in space and time.
Details
- Title: Subtitle
- Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis
- Creators
- Vegard Eldholm - Norwegian Institute of Public HealthJohn H-O Pettersson - Norwegian Institute of Public HealthOla B Brynildsrud - Norwegian Institute of Public HealthAndrew Kitchen - University of IowaErik Michael Rasmussen - Statens Serum InstitutTroels Lillebaek - Statens Serum InstitutJanne O Rønning - Norwegian Institute of Public HealthValeriu Crudu - Phthisiopneumology InstituteAnne Torunn Mengshoel - Norwegian Institute of Public HealthNadia Debech - Norwegian Institute of Public HealthKristian Alfsnes - Norwegian Institute of Public HealthJon Bohlin - Norwegian Institute of Public HealthCaitlin S Pepperell - University of Wisconsin–MadisonFrancois Balloux - University College London
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.113(48), pp.13881-13886
- DOI
- 10.1073/pnas.1611283113
- PMID
- 27872285
- PMCID
- PMC5137683
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Grant note
- R01 AI113287 / NIAID NIH HHS
- Language
- English
- Date published
- 11/29/2016
- Academic Unit
- Anthropology; International Programs
- Record Identifier
- 9984270195602771
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