Journal article
Aromatase inhibitors and calcium absorption in early stage breast cancer
Breast cancer research and treatment, Vol.134(1), pp.245-251
07/01/2012
DOI: 10.1007/s10549-012-1982-z
PMCID: PMC3376688
PMID: 22350731
Abstract
To investigate the effect of aromatase inhibitors (AI) on intestinal calcium absorption, measured using the gold-standard dual stable calcium isotope method. In this pilot study, we recruited 10 postmenopausal women with hormone receptor-positive breast cancer who planned to initiate AI therapy; women receiving chemotherapy were excluded. Women completed two 24 h inpatient calcium absorption study visits, the first prior to AI therapy and the second at least 6 weeks following onset of AI therapy. We calculated total fractional calcium absorption (TFCA) using the dose-corrected fractional recovery of two stable isotopes from 24 h urine collections. Ten postmenopausal women (mean +/- A SD age, 66 +/- A 7 years; 25(OH)D 40 +/- A 7 ng/mL, and total calcium intake of 1,714 +/- A 640 mg/day) exhibited no change in TFCA related to AI therapy (0.155 +/- A 0.042 prior to and 0.160 +/- A 0.064 following AI therapy, p = 1.0). Subjects exhibited a surprisingly small decline in serum estradiol levels with AI therapy that was not statistically significant. However, there was a significant correlation between duration of AI therapy and the decline in serum estradiol levels (r = -0.65, p = 0.040). In this pilot study, AI therapy did not decrease TFCA. Women with early stage breast cancer exhibited an unexpectedly low TFCA, most likely due to their high calcium intake. The null effect of AI therapy on TFCA might relate to the brief duration of AI therapy, the minimal effect of AI therapy on estradiol levels, subjects' high calcium intake or excellent vitamin D status.
Details
- Title: Subtitle
- Aromatase inhibitors and calcium absorption in early stage breast cancer
- Creators
- Amye Tevaarwerk - Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USAMark E. Burkard - Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USAKari B. Wisinski - Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USAMartin M. Shafer - Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USALisa A. Davis - Univ Wisconsin, Inst Clin & Translat Clin Res, Madison, WI 53705 USAJyothi Gogineni - Centegra Hlth Syst, Crystal Lake, IL USAElizabeth Crone - Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USAKaren E. Hansen - Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53705 USA
- Resource Type
- Journal article
- Publication Details
- Breast cancer research and treatment, Vol.134(1), pp.245-251
- DOI
- 10.1007/s10549-012-1982-z
- PMID
- 22350731
- PMCID
- PMC3376688
- NLM abbreviation
- Breast Cancer Res Treat
- ISSN
- 0167-6806
- eISSN
- 1573-7217
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- K23AR050995 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) UL1RR025011 / National Center for Research Resources, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30CA014520 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K23 AR050995; R01 AG028739 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Atlantic Philanthropies UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) American College of Rheumatology/Research Education Foundation UL1RR025011 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) American Society for Specialty Physicians through the Hartford Foundation R01AG028739 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 07/01/2012
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984700652902771
Metrics
16 Record Views